Mannose Receptor (CD206) Recombinant Rabbit Monoclonal Antibody [JF0953]

About this product

CD206, also known as macrophage mannose receptor type C (MMR or MRC1), is a type I membrane receptor protein. It is an phagocytic and endocytic receptor that can recognize carbohydrate ligands in target molecules. The extracellular portion of the protein includes eight C-type carbohydrate recognition domains (CRD) which are clustered together to achieve higher affinity binding to saccharides. CD206 is found on macrophages and on endothelial cells of the liver and is the only known example of a C-type lectin that contains multiple C-type CRDs. CD206 mediates the endocytosis of glycoproteins by macrophages and binds high-mannose structures on the surface of potentially pathogenic viruses, fungi and bacteria enabling them to be neutralized by phagocytic engulfment. During inflammation, CD206 is crucial for rapid clearance of several mannose-bearing serum glycoproteins but does not regulate the initiation of inflammation. CD206 is primarily expressed in mature tissue macrophages and immature dendritic cells, as well as hepatic and lymphatic endothelial cells, retinal pigmental epithelium (RPE) and mesangial cells.

Specifications

Catalog number

ET1702-04

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

Yes

CAS Number

9000-83-3

Product Name Alternative

bA541I19.1 antibody C type lectin domain family 13 member D antibody C-type lectin domain family 13 member D antibody CD 206 antibody CD206 antibody CD206 antigen antibody CLEC13D antibody CLEC13DL antibody Macrophage mannose receptor 1 antibody Macrophage mannose receptor 1 like protein 1 antibody Macrophage mannose receptor antibody Mannose receptor C type 1 antibody Mannose receptor C type 1 like 1 antibody MMR antibody MRC 1 antibody MRC1 antibody MRC1_HUMAN antibody MRC1L1 antibody OTTHUMP00000045206 antibody

Abbreviation

MMR, hMR, MRC1

Swiss Prot

P22897 Human, Q61830 Mouse

Cellular Locus

Endosome membrane, Cell membrane.

Host

Rabbit

Species Reactivity

Human, Mouse

Immunogen

Synthetic peptide within Human CD206 aa 1,407-1,456 / 1,456.

Isotype

IgG

Conjugation

Non-conjugated

Type

Recombinant Rabbit monoclonal Antibody

Applications

WB, IF-Cell, FC

Positive Control

Human lung tissue lysate, HepG2 cell lysate, mouse lung tissue lysate, D3 cell lysate, 293T cell lysate, MCF-7 cell lysate, HepG2.

Concentration

1 mg/mL

Dilution

WB: 1:1,000-1:5,000 ;IF-Cell: 1:100 ;FC: 1:500-1:1,000

Purity

Protein A affinity purified.

Form

Liquid

Buffer

1*TBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

Predicted band size: 166 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Recombinant Antibody

Yes