Transferrin Receptor (CD71) Recombinant Rabbit Monoclonal Antibody [JF0956]

About this product

CD71, also known as the transferrin receptor (TFR), is a type II membrane glycoprotein that exists as a disulfide-linked homodimer of two identical subunits. CD71 binds to two molecules of transferrin and a serum iron-transport protein, and directs the cellular uptake of iron via receptor-mediated endocytosis. CD71 is expressed, typically at high levels, on all proliferating cells, reticulocytes and erythroid precursors. It is not expressed on resting leukocytes, but is upregulated upon activation of lymphocytes, monocytes and macrophages. CD71 is also found on most dividing cells and on brain endothelium. A second transferrin receptor, TFR2, also mediates the uptake of transferrin-bound iron. TFR2 is a two-subunit homodimer and is highly expressed in liver as well as in hepatocytes and erythroid precursors. Mutations in the TFR2 gene result in hereditary hemochromatosis type III (HFE3), an iron overloading disorder predominant in Caucasians.

Specifications

Catalog number

ET1702-06

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

Yes

CAS Number

9000-83-3

Product Name Alternative

CD 71 antibody CD71 antibody CD71 antigen antibody IMD46 antibody OTTHUMP00000208523 antibody OTTHUMP00000208524 antibody OTTHUMP00000208525 antibody p90 antibody sTfR antibody T9 antibody TFR 1 antibody TfR antibody TfR1 antibody TFR1_HUMAN antibody TFRC antibody TR antibody Transferrin receptor (p90 CD71) antibody Transferrin receptor protein 1, serum form antibody Trfr antibody

Abbreviation

TR, TfR, TfR1, Trfr, TFRC

Swiss Prot

P02786 Human, Q62351 Mouse, Q99376 Rat

Cellular Locus

Cell membrane, Melanosome, Secreted.

Host

Rabbit

Species Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide within Human CD71 aa 22-60 / 760.

Isotype

IgG

Conjugation

Non-conjugated

Type

Recombinant Rabbit monoclonal Antibody

Applications

WB, IP, FC

Positive Control

HeLa cell lysate, K-562 cell lysate, SW480 cell lysate, U-87 MG cell lysate, RAW264.7 cell lysate, mouse spleen tissue lysate, rat spleen tissue lysate, Hela.

Concentration

1 mg/mL

Dilution

WB: 1:1,000-1:5,000 ;FC: 1:50-1:100 ;IP: Use at an assay dependent concentration.

Purity

Protein A affinity purified.

Form

Liquid

Buffer

1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

Predicted band size: 85 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Recombinant Antibody

Yes