Peroxiredoxin 1 Recombinant Rabbit Monoclonal Antibody [JF0945]

About this product

The peroxiredoxin (PRX) family comprises six antioxidant proteins, PRX I, II, III, IV, V and VI, which protect cells from reactive oxygen species (ROS) by preventing the metal-catalyzed oxidation of enzymes. The PRX proteins primarily utilize thioredoxin as the electron donor for antioxidation, although they are fairly promiscuous with regard to the hydroperoxide substrate. In addition to protection from ROS, peroxiredoxins are also involved in cell proliferation, differentiation and gene expression. PRX I, II, IV and VI show diffuse cytoplasmic localization, while PRX III and V exhibit distinct mitochondrial localization. The human PRX I gene encodes a protein that is expressed in several tissues, including liver, kidney, testis, lung and nervous system. PRX II is expressed in testis, while PRX III shows expression in lung. PRX I, II and III are overexpressed in breast cancer and may be involved in its development or progression. Upregulated protein levels of PRX I and II in Alzheimer's disease (AD) and Down syndrome (DS) indicate the involvement of PRX I and II in their pathogenesis. The human PRX IV gene is abundantly expressed in many tissues.

Specifications

Catalog number

ET1702-08

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9000-83-3

Product Name Alternative

Heme binding 23 kDa protein antibody MSP23 antibody Natural killer cell-enhancing factor A antibody NKEF A antibody NKEF-A antibody NKEFA antibody OSF3 antibody Osteoblast specific factor 3 antibody PAG antibody Paga antibody PAGB antibody Peroxiredoxin-1 antibody PRDX1 antibody PRDX1_HUMAN antibody Proliferation associated gene A antibody Proliferation-associated gene protein antibody PRX1 antibody PrxI antibody TDPX2 antibody Thioredoxin peroxidase 2 antibody Thioredoxin-dependent peroxide reductase 2 antibody

Abbreviation

NKEF-A, PAG, PRDX1

Swiss Prot

Q06830 Human, P35700 Mouse

Cellular Locus

Cytoplasm, Melanosome.

Host

Rabbit

Species Reactivity

Human, Mouse

Immunogen

Synthetic peptide within N-terminal human Peroxiredoxin 1.

Isotype

IgG

Conjugation

Non-conjugated

Type

Recombinant Rabbit monoclonal Antibody

Applications

WB, IF-Tissue, IHC-P

Positive Control

HeLa cell lysate, NIH/3T3 cell lysate, Mouse brain tissue lysate, human liver cancer tissue, mouse kidney tissue, human kidney tissue.

Concentration

1 mg/mL

Dilution

WB: 1:1,000-1:5,000 ;IF-Tissue: 1:100-1:500 ;IHC-P: 1:200-1:1,000

Purity

Protein A affinity purified.

Form

Liquid

Buffer

1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

Predicted band size: 22 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Recombinant Antibody

Yes