FOXP3 Recombinant Rabbit Monoclonal Antibody [JF0898]

About this product

The FOX family of transcription factors is a large group of proteins that share a common DNA binding domain termed a winged-helix or forkhead domain. During early development, FOXP1 and FOXP2 are expressed abundantly in the lung, with lower levels of expression in neural, intestinal and cardiovascular tissues, where they act as transcription repressors. FOXP1 is widely expressed in adult tissues, while neoplastic cells often exhibit a dramatic change in expression level or localization of FOXP1. The gene encoding human FOXP1 maps to chromosome 3p14.1, and the gene encoding human FOXP2 maps to chromosome 7q31. The gene encoding FOXP3, a third member of this family, maps to chromosome Xp11.23. Mutations in this gene cause IPEX, a fatal, X-linked inherited disorder characterized by immune dysregulation. The FOXP3 protein, also known as scurfin, is essential for normal immune homeostasis. Specifically, FOXP3 represses transcription through a DNA binding forkhead domain, thereby regulating T cell activation.

Specifications

Catalog number

ET1702-12

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9000-83-3

Product Name Alternative

AIID antibody DIETER antibody Forkhead box P3 antibody Forkhead box protein P3 antibody FOXP3 antibody FOXP3_HUMAN antibody FOXP3delta7 antibody Immune dysregulation polyendocrinopathy enteropathy X linked antibody Immunodeficiency polyendocrinopathy enteropathy X linked antibody IPEX antibody JM2 antibody MGC141961 antibody MGC141963 antibody OTTHUMP00000025832 antibody OTTHUMP00000025833 antibody OTTHUMP00000226737 antibody PIDX antibody Scurfin antibody XPID antibody

Abbreviation

FOXP3

Swiss Prot

Q9BZS1 Human, Q99JB6 Mouse,

Cellular Locus

Nucleus, Cytoplasm.

Host

Rabbit

Species Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein within human FOXP3 aa 250-431.

Isotype

IgG

Conjugation

Non-conjugated

Type

Recombinant Rabbit monoclonal Antibody

Applications

WB, IF-Cell, FC, IHC-P

Positive Control

K562 cell lysates, MCF-7, 293T, Jurkat, human lymph node tissue, human tonsil tissue, mouse spleen tissue, rat spleen tissue.

Concentration

1 mg/mL

Dilution

WB: 1:500-1:2,000 ;IF-Cell: 1:50-1:100 ;FC: 1:50-1:100 ;IHC-P: 1:200

Purity

Protein A affinity purified.

Form

Liquid

Buffer

1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

Predicted band size: 47 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Recombinant Antibody

Yes