MMP-13 Recombinant Rabbit Monoclonal Antibody [JF0893]

About this product

The matrix metalloproteinases (MMP) are a family of peptidase enzymes responsible for the degradation of extracellular matrix components, including collagen, gelatin, fibronectin, laminin and proteoglycan. Transcription of MMP genes is differentially activated by phorbol ester, lipopolysaccharide (LPS) or staphylococcal enterotoxin B (SEB). MMP catalysis requires both calcium and zinc. MMP-13 (also designated collagenase-3) is produced by breast carcinomas and degrades collagen types I, II and III. MMP-13 has wide substrate specificity, and its physiologic expression is limited to situations in which rapid and effective remodeling of collagenous ECM takes place, such as fetal bone development and adult bone remodeling.

Specifications

Catalog number

ET1702-14

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9000-83-3

Product Name Alternative

CLG 3 antibody CLG3 antibody Collagenase 3 antibody Collagenase3 antibody MANDP1 antibody Matrix metallopeptidase 13 (collagenase 3) antibody Matrix Metalloproteinase 13 antibody Matrix metalloproteinase-13 antibody MMP 13 antibody MMP-13 antibody Mmp13 antibody MMP13_HUMAN antibody

Abbreviation

MMP-13, MMP13

Swiss Prot

P45452 Human

Cellular Locus

Extracellular matrix, Secreted.

Host

Rabbit

Species Reactivity

Human

Immunogen

Synthetic peptide within human MMP13 aa 390-430.

Isotype

IgG

Conjugation

Non-conjugated

Type

Recombinant Rabbit monoclonal Antibody

Applications

WB, IF-Cell, IF-Tissue, IHC-P, FC

Positive Control

HeLa cell lysate, HEK-293 cell lysate, Jurkat cell lysate, MDA-MB-231 cell lysate, SW480 cell lysate, HeLa, human breast tissue.

Concentration

1 mg/mL

Dilution

WB: 1:2,000 ;IF-Cell: 1:100 ;IF-Tissue: 1:50-1:200 ;IHC-P: 1:50-1:200 ;FC: 1:1,000

Purity

Protein A affinity purified.

Form

Liquid

Buffer

1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

Predicted band size: 54 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Recombinant Antibody

Yes