FOXP1 Recombinant Rabbit Monoclonal Antibody [JF1017]

About this product

The FOX family of transcription factors is a large group of proteins that share a common DNA binding domain termed a winged-helix or forkhead domain. During early development, FOXP1 and FOXP2 are expressed abundantly in the lung with lower levels of expression in neural, intestinal and cardiovascular tissues, where they act as transcription repressors. FOXP1 is widely expressed in adult tissues, while neoplastic cells often exhibit a dramatic change in expression level or localization of FOXP1. The gene encoding human FOXP1 maps to chromosome 3p14.1. The gene encoding human FOXP2 maps to chromosome 7q31. The gene encoding FOXP3, a third member of this family, maps to chromosome Xp11.23-Xq13.3. Mutations in this gene cause IPEX, a fatal, X-linked inherited disorder characterized by immune dysregulation. The FOXP3 protein, also known as scurfin, is essential for normal immune homeostasis. Specifically, FOXP3 represses transcription through a DNA binding forkhead domain, thereby regulating T-cell activation.

Specifications

Catalog number

ET1702-44

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9000-83-3

Product Name Alternative

12CC4 antibody FLJ23741 antibody Fork head related protein like B antibody Forkhead box P1 antibody Forkhead box protein P1 antibody FOX P1 antibody FOXP 1 antibody foxp1 antibody FOXP1_HUMAN antibody Glutamine rich factor 1 antibody hFKH1B antibody HSPC215 antibody MGC12942 antibody MGC88572 antibody MGC99551 antibody QRF 1 antibody QRF1 antibody

Abbreviation

MFH, FOXP1

Swiss Prot

Q9H334 Human, P58462 Mouse, Q498D1 Rat

Cellular Locus

Nucleus.

Host

Rabbit

Species Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide within human FOXP1 aa 615-653 / 677.

Isotype

IgG

Conjugation

Non-conjugated

Type

Recombinant Rabbit monoclonal Antibody

Applications

WB, IHC-P, FC

Positive Control

Hela cell lysate, Jurkat cell lysate, MCF-7 cell lysate, human colon carcinoma tissue, human breast carcinoma tissue, MCF-7.

Concentration

1 mg/mL

Dilution

WB: 1:1,000-1:5,000 ;FC: 1:50-1:100 ;IHC-P: 1:50-1:200

Purity

Protein A affinity purified.

Form

Liquid

Buffer

1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

77/75 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Recombinant Antibody

Yes