Galectin 3 Recombinant Rabbit Monoclonal Antibody [JF39-10]

About this product

Galectins are a family of soluble b-galactoside-binding animal lectins that modulate cell-to-cell adhesion and cell-to-extracellular matrix (ECM) inter- actions and play a role in tumor progression, pre-mRNA splicing and apop-tosis. The galectin-3 protein, also known as Mac-2, hMac-2, GALBP, CBP35 or LGALS3, contains a single carbohydrate binding domain, which binds galactose-containing glycoconjugates. Galectin-3 is expressed in colonic and intestinal epithelium, inflammatory macrophages, papillary and follicular carcinomas, neoplastic astrocytes and some B and T lymphocytes. Upregulated expression of galectin-3 is involved in cancer progression and metastasis. Galectin-3 mediates the endocytosis of β1 Integrins in a lactose-dependent manner and is associated with thyroid malignancy and Crohn's disease. It may also be used as a marker for diagnosing cases involving Hurthle cell adenomas and carcinomas.

Specifications

Catalog number

ET1702-48

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9000-83-3

Product Name Alternative

35 kDa lectin antibody Carbohydrate binding protein 35 antibody Carbohydrate-binding protein 35 antibody CBP 35 antibody CBP35 antibody Gal-3 antibody GAL3 antibody Galactose-specific lectin 3 antibody Galactoside-binding protein antibody GALBP antibody Galectin 3 internal gene,included antibody Galectin-3 antibody Galectin 3 antibody Galectin3 antibody GALIG antibody GBP antibody IgE binding protein antibody IgE-binding protein antibody L 31 antibody L 34 antibody L-31 antibody L-34 galactoside-binding lectin antibody L31 antibody Laminin-binding protein antibody Lectin L-29 antibody Lectin, galactose binding, soluble 3 antibody LEG3_HUMAN antibody LGALS2 antibody LGALS3 antibody MAC 2 antigen antibody Mac-2 antibody Mac-2 antigen antibody MAC2 antibody Macrophage galactose-specific lectin antibody MGC105387 antibody

Abbreviation

Gal-3, CBP 35, GALBP, LGALS3

Swiss Prot

P17931 Human, P16110 Mouse, P08699 Rat

Cellular Locus

Nucleus, Secreted, Cytoplasm.

Host

Rabbit

Species Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide within Human Galectin 3 aa 1-49 / 250.

Isotype

IgG

Conjugation

Non-conjugated

Type

Recombinant Rabbit monoclonal Antibody

Applications

WB, IF-Cell, IF-Tissue, FC, IHC-P

Positive Control

NIH/3T3 cell lysate, Hela cell lysate, THP-1 cell lysate, HeLa, human thyroid carcinoma tissue, human colon tissue, rat bladder tissue.

Concentration

1 mg/mL

Dilution

WB: 1:500-1:2,000 ;IF-Cell: 1:50-1:200 ;IF-Tissue: 1:50-1:200 ;FC: 1:1,000 ;IHC-P: 1:200-1:1,000

Purity

Protein A affinity purified.

Form

Liquid

Buffer

1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

Predicted band size: 26 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Recombinant Antibody

Yes