PDGFR alpha Recombinant Rabbit Monoclonal Antibody [JF104-6] — image 1 of 3

Product details

PDGFR alpha Recombinant Rabbit Monoclonal Antibody [JF104-6]

Catalog number ET1702-49

Discontinued

Price for ET1702-49

Size / count 100 µL

This variant is discontinued and cannot be added to your cart.

About this product

Platelet-derived growth factor (PDGF) is a mitogen for mesenchyme- and glia-derived cells. PDGF consists of two chains, A and B, which dimerize to form functionally distinct isoforms, PGDF-AA, PDGF-AB and PDGF-BB. These three isoforms bind with different affinities to two receptor types, PDGFR-α and -β, which are endowed with protein tyrosine kinase domains. PDGFR-α can bind to both A and B subunits of PDGF, while PDGFR-β can only bind the B subunit. Ligand binding promotes either homo- or heterodimerization of the PDGF receptors in a specific manner. PDGF-AA induces the dimerization of two α receptors, PDGF-AB induces dimerization of αα and αβ and PDGF-BB induces the formation of three types of dimers, αα, αβ and ββ. Translocation of the PDGFR-β gene with the Tel gene is linked to chronic myelomonocytic leukemia (CMML), a myelodysplastic syndrome, and demonstrates the oncogenic potential of the PDGF receptors.

Specifications

Catalog number: ET1702-49
Size / count: 100 µL
Dry ice: No
Hazardous: No
Discontinued: Yes
CAS Number: 9000-83-3
Product Name Alternative: Alpha-type platelet-derived growth factor receptor antibody CD140 antigen-like family member A antibody CD140a antibody CD140a antigen antibody MGC74795 antibody PDGF alpha chain antibody PDGF-R-alpha antibody PDGFR 2 antibody PDGFR alpha antibody PDGFR2 antibody PDGFRA antibody PDGFRA/BCR fusion antibody PGFRA_HUMAN antibody Platelet derived growth factor receptor 2 antibody Platelet derived growth factor receptor alpha antibody Platelet derived growth factor receptor alpha polypeptide antibody Platelet derived growth factor receptor antibody Rearranged in hypereosinophilia platelet derived growth factor receptor alpha fusion protein antibody RHEPDGFRA antibody
Abbreviation: PDGFR-alpha, PDGFR-2, PDGFRA
Swiss Prot: P16234 Human, P26618 Mouse, P20786 Rat
Cellular Locus: Golgi apparatus, Cell membrane, cilium.
Host: Rabbit
Species Reactivity: Human, Mouse, Rat
Immunogen: Synthetic peptide within C-terminal human PDGFR alpha.
Isotype: IgG
Conjugation: Non-conjugated
Type: Recombinant Rabbit monoclonal Antibody
Applications: WB, IHC-P, FC, IHC-Fr
Positive Control: Mouse embryonic femur tissue, mouse embryonic intervertebral disc tissue, mouse embryonic lung tissue, rat embryonic femur tissue, rat embryonic intervertebral disc tissue, rat embryonic lung tissue, rat endometrium tissue, human colon tissue, human colon cancer tissue, human glioblastoma tissue, NIH/3T3 cell lysates, SHG-44 cell lysates, A549, NIH/3T3.
Concentration: 1 mg/mL
Dilution: WB: 1:1,000 ;IHC-P: 1:500-1:2,000 ;IHC-Fr: 1:200 ;FC: 1:50-1:100
Purity: Protein A affinity purified.
Form: Liquid
Buffer: 1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight: Predicted band size: 123 kDa
Storage Conditions: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Recombinant Antibody: Yes

Frequently Asked Questions

What is the catalog number for PDGFR alpha Recombinant Rabbit Monoclonal Antibody [JF104-6]?

The catalog number for PDGFR alpha Recombinant Rabbit Monoclonal Antibody [JF104-6] is ET1702-49.

Is PDGFR alpha Recombinant Rabbit Monoclonal Antibody [JF104-6] in stock?

PDGFR alpha Recombinant Rabbit Monoclonal Antibody [JF104-6] is currently made to order / not held in immediate stock. Contact us for lead time.

What is PDGFR alpha Recombinant Rabbit Monoclonal Antibody [JF104-6] used for?

What should I do if I need to report a performance issue with a specific lot of this product?

Provide the catalogue number, product name, lot number, and your experimental results to our technical support team. They’ll investigate and, if needed, escalate to the manufacturer, provided the product was used before expiry and stored correctly.

What is the isotype of this antibody?

Isotype information such as IgG1 or IgG2a is listed in the product specifications on the datasheet, relevant for selecting compatible detection reagents.

Can I get a trial-size or discounted first order of this product?

We don’t generally offer free samples, but trial discounts in exchange for feedback and validation results are almost always possible. Contact us with your intended application to arrange one.