CD74 Recombinant Rabbit Monoclonal Antibody [JF40-10]

About this product

The human histocompatibility leukocyte antigen (HLA) class II-associated invariant chain is composed of at least four polypeptides. One of these polypeptide chains is expressed as a membrane-bound subunit and has been designated CD74. The loading of peptide onto the class II MHC protein (MHC II) appears to be regulated by CD74, which associates with MHC II during its migration to the endosomal compartment, where class II binds pep-tide. CD74 is expressed by cells of both T lymphocyte and B lymphocyte lineages. In fact, CD74 is broadly expressed in normal B lymphocytes, regardless of their histocompatibility leukocyte antigen (HLA) phenotype, while a subset of peripheral T lymphocytes that are MHC II negative do not express CD74.

Specifications

Catalog number

ET1702-51

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9000-83-3

Product Name Alternative

CD 74 antibody CD74 antibody CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated) antibody CD74 antigen antibody CD74 molecule antibody CD74 molecule, major histocompatibility complex, class II invariant chain antibody CLIP antibody DHLAG antibody Gamma chain of class II antigens antibody HG2A_HUMAN antibody HLA class II histocompatibility antigen gamma chain antibody HLA DR antigens associated invariant chain antibody HLA DR gamma antibody HLA-DR antigens-associated invariant chain antibody HLA-DR-gamma antibody HLADG antibody HLADR antigens associated invariant chain antibody Ia antigen associated invariant chain antibody Ia antigen-associated invariant chain antibody Ia associated invariant chain antibody Ia gamma antibody Ii antibody Invariant polypeptide of major histocompatibility complex class II antigen associated antibody la-gamma antibody Major histocompatibility complex class II invariant chain antibody MHC HLA DR gamma chain antibody MHC HLA-DR gamma chain antibody p33 antibody p35 antibody Protein 41 antibody

Abbreviation

Ii, CD74

Swiss Prot

P04233 Human

Cellular Locus

Endoplasmic reticulum membrane, trans-Golgi network, cell membrane, lysosome, endosome.

Host

Rabbit

Species Reactivity

Human

Immunogen

Synthetic peptide within Human CD74 aa 21-64 / 296.

Isotype

IgG

Conjugation

Non-conjugated

Type

Recombinant Rabbit monoclonal Antibody

Applications

WB, IF-Cell, IF-Tissue, IHC-P, FC

Positive Control

Raji cell lysate, Jurkat cell lysate, Raji, human spleen tissue, human lymph nodes tissue, human tonsil tissue.

Concentration

1 mg/mL

Dilution

WB: 1:1,000-1:5,000 ;IF-Cell: 1:50-1:200 ;IF-Tissue: 1:50-1:500 ;IHC-P: 1:500 ;FC: 1:1,000

Purity

Protein A affinity purified.

Form

Liquid

Buffer

1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

Predicted band size: 34 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Recombinant Antibody

Yes