Annexin V Recombinant Rabbit Monoclonal Antibody [JF50-11]

About this product

The annexin family of calcium-binding proteins is composed of at least ten mammalian genes and is characterized by a conserved core domain, which binds phospholipids in a Ca²⁺-dependent manner, and a unique amino-terminal region, which may confer binding specificity. Annexin family members have been implicated as regulators of such diverse processes as ion flux, endocytosis and exocytosis, and cellular adhesion. For example, the crystal structure of Annexin III has suggested a hydrophilic amino-terminus with possible Ca²⁺ channel activity. Similarly, Annexin V has ion channel properties. Annexin IV, also referred to as endonexin, functions to regulate Cl-flux by mediating calmodulin kinase II (CaMKII) activity and Annexin V has been shown to regulate PKC activity. Annexin V is ubiquitously expressed at high levels in tissues and cells grown in tissue culture, while Annexin VIII exhibits a more limited distribution. Where co-expressed in the same tissues, Annexin VIII is often expressed at a 100-fold lower level than Annexin V. However, Annexin VIII is preferentially expressed in acute promyelocytic leukemia (APL) cells, which may relate to its role in hematopoietic cell differentiation.

Specifications

Catalog number

ET1702-62

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9000-83-3

Product Name Alternative

Anchorin CII antibody Annexin 5 antibody Annexin A5 antibody Annexin V antibody Annexin-5 antibody ANX A5 antibody ANX5 antibody ANXA5 antibody ANXA5_HUMAN antibody Calphobindin I antibody CBP-I antibody Endonexin II antibody ENX2 antibody Lipocortin V antibody PAP I antibody PAP-I antibody Placental anticoagulant protein 4 antibody Placental anticoagulant protein I antibody PLACENTAL PROTEIN 4 antibody Pp4 antibody Thromboplastin inhibitor antibody VAC-alpha antibody Vascular anticoagulant-alpha antibody

Abbreviation

CBP-I, PP4, PAP-I, VAC-alpha, ANXA5

Swiss Prot

P08758 Human, P48036 Mouse, P14668 Rat

Cellular Locus

Cytosol, collagen-containing extracellular matrix, endothelial microparticle, extracellular exosome, extracellular region, external side of plasma membrane, cytoplasm, focal adhesion, intracellular, membrane.

Host

Rabbit

Species Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide within Human Annexin V aa 281-320 / 320.

Isotype

IgG

Conjugation

Non-conjugated

Type

Recombinant Rabbit monoclonal Antibody

Applications

WB, FC

Positive Control

HeLa cell lysate, HepG2 cell lysate, Human liver tissue lysate, NIH/3T3 cell lysate, C2C12 cell lysate, Mouse liver tissue lysate, C6 cell lysate, PC-12 cell lysate, A549 cell lysate.

Concentration

1 mg/mL

Dilution

WB: 1:1,000

Purity

Protein A affinity purified.

Form

Liquid

Buffer

1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

Predicted band size: 36 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Recombinant Antibody

Yes