TBR1 Recombinant Rabbit Monoclonal Antibody [JF10-00]

About this product

A novel murine and human gene, TBR-1, encodes a putative transcription factor related to the Brachyrury (T) gene that is expressed only in postmitotic cells. T-brain-1 (TBR-1) mRNA is largely restricted to the cerebral cortex, where, during embryogenesis, it defines different regions that give rise to the palecortex, limbic cortex and neocortex. TBR-1, Pax-6 and Emx-1 are expressed in the mouse and chicken pallium. The pallio-subpallial boundary lies at the interface between the TBR-1 and Dlx-2 expression domains. Chicken genes homolgous to these mouse genes are expressed in topologically comparable patterns during development, suggesting that mouse and chicken may have similar histogenetic specification processes and field homologies. CASK/LIN-2, a membrane-associated guanylate kinase, is required for EGFR localization and signaling. In adult rat brain, CASK is concentrated at neuronal synapses and binds to the cell-surface proteins. CASK can interact with TBR-1, which is involved in forebrain development. CASK enters into the nucleus and binds to a specific DNA sequence (the T-element) in a complex with TBR-1. Thus, CASK acts as a coactivator of TBR-1 to induce transcription of T-element containing genes, including reelin.

Specifications

Catalog number

ET1702-97

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9000-83-3

Product Name Alternative

T box brain 1 antibody T box brain protein 1 antibody T brain 1 protein antibody T-box brain protein 1 antibody T-brain-1 antibody TBR 1 antibody TBR-1 antibody Tbr1 antibody TBR1_HUMAN antibody TES 56 antibody TES-56 antibody

Abbreviation

TBR-1

Swiss Prot

Q16650 Human, Q64336 Mouse,

Cellular Locus

Nucleus.

Host

Rabbit

Species Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide within Human TBR1 aa 30-75 / 682.

Isotype

IgG

Conjugation

Non-conjugated

Type

Recombinant Rabbit monoclonal Antibody

Applications

WB, IHC-P, IF-Tissue, mIHC, IHC-Fr

Positive Control

Human brain tissue lysates, mouse brain tissue lysates, rat brain tissue lysates, human brain tissue, mouse brain tissue, rat brain tissue, mouse hippocampus tissue, rat hippocampus tissue, E14.5 mouse embryonic brain tissue.

Concentration

1 mg/mL

Dilution

WB: 1:1,000 ;IHC-P: 1:500-1:2,000 ;IF-Tissue: 1:500 ;mIHC: 1:1,000 ;IHC-Fr: 1:500

Purity

Protein A affinity purified.

Form

Liquid

Buffer

1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

Predicted band size: 74 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Recombinant Antibody

Yes