ADAM17 Recombinant Rabbit Monoclonal Antibody [JM10-35]

About this product

A disintegrin and metalloprotease 17 (ADAM17), also called TACE (tumor necrosis factor-α-converting enzyme), is an 824-amino acid polypeptide that belongs to the ADAM protein family of disintegrins and metalloproteases. ADAM17 is understood to be involved in the processing of tumor necrosis factor alpha (TNF-α) at the surface of the cell, and from within the intracellular membranes of the trans-Golgi network. This process, which is also known as 'shedding', involves the cleavage and release of a soluble ectodomain from membrane-bound pro-proteins (such as pro-TNF-α), and is of known physiological importance. ADAM17 was the first 'sheddase' to be identified, and is also understood to play a role in the release of a diverse variety of membrane-anchored cytokines, cell adhesion molecules, receptors, ligands, and enzymes.

Specifications

Catalog number

ET1703-06

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

Yes

CAS Number

9000-83-3

Product Name Alternative

A disintegrin and metalloproteinase domain 17 (tumor necrosis factor, alpha, converting enzyme) antibody A disintegrin and metalloproteinase domain 17 antibody ADA17_HUMAN antibody ADAM 17 antibody ADAM metallopeptidase domain 17 antibody ADAM17 antibody ADAM17 protein antibody CD 156b antibody CD156b antibody CD156b antigen antibody CSVP antibody Disintegrin and metalloproteinase domain-containing protein 17 antibody MGC71942 antibody NISBD antibody NISBD1 antibody Snake venom like protease antibody Snake venom-like protease antibody TACE antibody TNF alpha convertase antibody TNF alpha converting enzyme antibody TNF-alpha convertase antibody TNF-alpha-converting enzyme antibody Tumor Necrosis Factor Alpha Converting Enzyme antibody

Abbreviation

ADAM 17

Swiss Prot

P78536 Human, Q9Z0F8 Mouse, Q9Z1K9 Rat

Cellular Locus

Membrane.

Host

Rabbit

Species Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide within Human ADAM17 aa 757-790 / 824.

Isotype

IgG

Conjugation

Non-conjugated

Type

Recombinant Rabbit monoclonal Antibody

Applications

WB, IF-Cell, IF-Tissue, FC, IP, IHC-Fr, IHC-P

Positive Control

SW480 cell lysate, HepG2 cell lysate, HepG2, SKOV-3, SW480, Hela, mouse cerebral cortex tissue, mouse hippocampus tissue, rat hippocampus tissue.

Concentration

1 mg/mL

Dilution

WB: 1:500 ;FC: 1:50-1:100 ;IF-Cell: 1:50-1:200 ;IF-Tissue: 1:50-1:200 ;IP: Use at an assay dependent concentration. ;IHC-Fr: 1:100 ;IHC-P: 1:500

Purity

Protein A affinity purified.

Form

Liquid

Buffer

1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

Predicted band size: 93 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Recombinant Antibody

Yes