Vitamin D Binding protein Recombinant Rabbit Monoclonal Antibody [JM10-36]

About this product

Vitamin D-binding protein (DBP), also/originally known as gc-globulin (group-specific component), is a protein that in humans is encoded by the GC gene. Vitamin D-binding protein belongs to the albumin gene family, together with human serum albumin and alpha-fetoprotein. It is a multifunctional protein found in plasma, ascitic fluid, cerebrospinal fluid and on the surface of many cell types. It is able to bind the various forms of vitamin D including ergocalciferol (vitamin D2) and cholecalciferol (vitamin D3), the 25-hydroxylated forms (calcifediol), and the active hormonal product, 1,25-dihydroxyvitamin D (calcitriol). The major proportion of vitamin D in blood is bound to this protein. It transports vitamin D metabolites between skin, liver and kidney, and then on to the various target tissues. As Gc protein-derived macrophage activating factor it is a Macrophage Activating Factor (MAF) that has been tested for use as a cancer treatment that would activate macrophages against cancer cells.

Specifications

Catalog number

ET1703-09

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9000-83-3

Product Name Alternative

DBP antibody DBP/GC antibody GC antibody Gc globulin antibody Gc-globulin antibody GRD3 antibody Group specific component antibody Group specific component vitamin D binding protein antibody Group-specific component antibody hDBP antibody VDB antibody VDBG antibody VDBP antibody Vitamin D binding alpha globulin antibody Vitamin D-binding protein antibody VTDB_HUMAN antibody

Abbreviation

DBP, VDB, Gc-MAF, Gc, DBP-maf

Swiss Prot

P02774 Human

Cellular Locus

Secreted.

Host

Rabbit

Species Reactivity

Human

Immunogen

Synthetic pertide within Human Vitamin D Binding protein aa 270-319 / 474.

Isotype

IgG

Conjugation

Non-conjugated

Type

Recombinant Rabbit monoclonal Antibody

Applications

WB, IF-Cell, IF-Tissue, IHC-P, FC

Positive Control

Human lung tissue lysates, Hela, HepG2, SKOV-3, human kidney tissue.

Concentration

1 mg/mL

Dilution

WB: 1:1,000-1:2,000;IF-Cell: 1:50-1:200;IF-Tissue: 1:50-1:200;IHC-P: 1:50-1:200;FC: 1:50-1:100

Purity

Protein A affinity purified.

Form

Liquid

Buffer

1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

Predicted band size: 53 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Recombinant Antibody

Yes