IgA Recombinant Rabbit Monoclonal Antibody [JM10-42]

About this product

Immunoglobulin A (IgA, also referred to as sIgA in its secretory form) is an antibody that plays a role in the immune function of mucous membranes. The amount of IgA produced in association with mucosal membranes is greater than all other types of antibody combined. In absolute terms, between three and five grams are secreted into the intestinal lumen each day. This represents up to 15% of total immunoglobulins produced throughout the body. IgA has two subclasses (IgA1 and IgA2) and can be produced as a monomeric as well as a dimeric form. The IgA dimeric form is the most prevalent and is also called secretory IgA (sIgA). sIgA is the main immunoglobulin found in mucous secretions, including tears, saliva, sweat, colostrum and secretions from the genitourinary tract, gastrointestinal tract, prostate and respiratory epithelium. It is also found in small amounts in blood. The secretory component of sIgA protects the immunoglobulin from being degraded by proteolytic enzymes; thus, sIgA can survive in the harsh gastrointestinal tract environment and provide protection against microbes that multiply in body secretions. sIgA can also inhibit inflammatory effects of other immunoglobulins. IgA is a poor activator of the complement system, and opsonizes only weakly.

Specifications

Catalog number

ET1703-10

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9000-83-3

Product Name Alternative

Hepatocellular carcinoma-associated protein TB6 antibody Ig alpha 1 chain C region antibody Ig alpha 2 chain C region antibody IGHA antibody IGHA1 antibody IGHA2 antibody Immunoglobulin heavy constant alpha 1 antibody Immunoglobulin heavy constant alpha 2 A2m marker antibody Immunoglobulin heavy constant alpha 2 antibody PIgR antibody Poly-Ig receptor antibody polymeric immunoglobulin receptor antibody polymeric immunoglobulin receptor Secretory component antibody

Abbreviation

IGHA1, IGHA2

Swiss Prot

P01876 Human, P01877 Human

Cellular Locus

Cell membrane, Secreted.

Host

Rabbit

Species Reactivity

Human

Immunogen

Recombinant full length protein of Human IgA aa 1-353 / 353.

Isotype

IgG

Conjugation

Non-conjugated

Type

Recombinant Rabbit monoclonal Antibody

Applications

WB, IF-Cell, IF-Tissue, IHC-P, IP

Positive Control

Human plasma lysates, HepG2, human tonsil tissue, human spleen tissue.

Concentration

1 mg/mL

Dilution

WB: 1:1,000 ;IF-Cell: 1:50-1:200 ;IF-Tissue: 1:50-1:200 ;IHC-P: 1:50-1:200 ;IP: Use at an assay dependent concentration.

Purity

Protein A affinity purified.

Form

Liquid

Buffer

1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

Predicted band size: 38 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Recombinant Antibody

Yes