PGP9.5 Recombinant Rabbit Monoclonal Antibody [JM10-59]

About this product

UCH-L1 (ubiquitin C-terminal hydrolase) is a member of a gene family whose products hydrolyze small C-terminal adducts of ubiquitin to generate the ubiquitin monomer. Expression of UCH-L1 is highly specific to neurons and to cells of the diffuse neuroendocrine system and their tumors. UCH-L1 is expressed in brain neurons. Examination of specific brain regions reveals expression in all areas tested, particularly in the substantia nigra. UCH-L1 represents 1-2% of total soluble brain protein. Its occurrence in Lewy bodies and its function in the proteasome pathway make it a compelling candidate gene in Parkinson disease. The gene which encodes UCH-L1 maps to human chromosome 4p13. The 230 amino acid human UCH-L3 protein is 54% identical to that of UCH-L1. UCH-L3 is the predominant thiol protease and has high-affinity binding sites for ubiquitin.

Specifications

Catalog number

ET1703-22

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

Yes

CAS Number

9000-83-3

Product Name Alternative

Epididymis luminal protein 117 antibody Epididymis secretory protein Li 53 antibody HEL 117 antibody HEL S 53 antibody NDGOA antibody Neuron cytoplasmic protein 9.5 antibody OTTHUMP00000218137 antibody OTTHUMP00000218139 antibody OTTHUMP00000218140 antibody OTTHUMP00000218141 antibody Park 5 antibody PARK5 antibody PGP 9.5 antibody PGP9.5 antibody PGP95 antibody Protein gene product 9.5 antibody Ubiquitin C terminal esterase L1 antibody Ubiquitin C terminal hydrolase antibody Ubiquitin C terminal hydrolase L1 antibody Ubiquitin carboxyl terminal esterase L1 antibody Ubiquitin carboxyl terminal hydrolase isozyme L1 antibody Ubiquitin carboxyl-terminal hydrolase isozyme L1 antibody Ubiquitin thioesterase L1 antibody Ubiquitin thiolesterase antibody Ubiquitin thiolesterase L1 antibody UCH-L1 antibody UCHL1 antibody UCHL1_HUMAN antibody

Abbreviation

UCH-L1, PGP9.5, UCHL1

Swiss Prot

P09936 Human, Q9R0P9 Mouse, Q00981 Rat

Cellular Locus

Cytoplasm, Endoplasmic reticulum membrane.

Host

Rabbit

Species Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide within Human PGP95 aa 191-223 / 223.

Isotype

IgG

Conjugation

Non-conjugated

Type

Recombinant Rabbit monoclonal Antibody

Applications

WB, IF-Cell, IF-Tissue, IHC-P, IP, FC, IHC-Fr

Positive Control

A-172 cell lysate, SHG-44 cell lysate, U-87 MG cell lysate, SH-SY5Y cell lysate, NCI-H1299 cell lysate, A549 cell lysate, 293T cell lysate, Neuro-2a cell lysate, C6 cell lysate, PC-12 cell lysate, mouse brain tissue lysate, rat brain tissue lysate, N2A, PC-12, mouse spinal cord tissue, mouse skin tissue, mouse brain tissue, mouse colon tissue, mouse cerebrum tissue.

Concentration

1 mg/mL

Dilution

WB: 1:2,000-1:5,000 ;IF-Cell: 1:100-1:500 ;IF-Tissue: 1:100-1:1,000 ;IHC-P: 1:1,000-1:5,000 ;IP: Use at an assay dependent concentration. ;FC: 1:1,000 ;IHC-Fr: 1:200-1:500

Purity

Protein A affinity purified.

Form

Liquid

Buffer

1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

Predicted band size: 25 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Recombinant Antibody

Yes