XBP1 Recombinant Rabbit Monoclonal Antibody [JM10-62]

About this product

X-box binding protein 1, also known as XBP1, is a protein which in humans is encoded by the XBP1 gene. The XBP1 protein is a transcription factor that regulates the expression of genes important to the proper functioning of the immune system and in the cellular stress response. It was first identified by its ability to bind to the Xbox, a conserved transcriptional element in the promoter of the human leukocyte antigen (HLA) DR alpha. Abnormalities in XBP1 lead to a heightened ER stress and subsequently causes a heightened susceptibility for inflammatory processes that may contribute to Alzheimer's disease. In the colon, XBP1 anomalies have been linked to Crohn's disease.

Specifications

Catalog number

ET1703-23

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9000-83-3

Product Name Alternative

Tax responsive element binding protein 5 antibody Tax-responsive element-binding protein 5 antibody TREB5 antibody X box binding protein 1 antibody X box binding protein 2 antibody X-box-binding protein 1 antibody XBP 1 antibody XBP-1 antibody XBP1 antibody XBP1_HUMAN antibody XBP2 antibody

Abbreviation

XBP-1, TREB-5

Swiss Prot

P17861 Human, O35426 Mouse

Cellular Locus

Nucleus, Chromosome.

Host

Rabbit

Species Reactivity

Human, Mouse

Immunogen

Synthetic peptide within Human XBP1 aa 126-175 / 261.

Isotype

IgG

Conjugation

Non-conjugated

Type

Recombinant Rabbit monoclonal Antibody

Applications

WB, IHC-P, IF-Cell, IF-Tissue, FC

Positive Control

293T cell lysate, HepG2 cell lysate, Hela, HepG2, SW480, human colon carcinoma tissue, mouse liver tissue, 293T.

Concentration

1 mg/mL

Dilution

WB: 1:500-1:1,000 ;IF-Cell: 1:100-1:500 ;IF-Tissue: 1:100-1:500 ;IHC-P: 1:50-1:200 ;FC: 1:50-1:100

Purity

Protein A affinity purified.

Form

Liquid

Buffer

1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

Predicted band size: 29 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Recombinant Antibody

Yes