EDG1 Recombinant Rabbit Monoclonal Antibody [JM10-66]

About this product

Sphingosine-1-phosphate receptor 1 (S1P receptor 1 or S1PR1), also known as endothelial differentiation gene 1 (EDG1) is a protein that in humans is encoded by the S1PR1 gene. S1PR1 is a G-protein-coupled receptor which binds the bioactive signaling molecule sphingosine 1-phosphate (S1P). S1PR1 belongs to a sphingosine-1-phosphate receptor subfamily comprising five members (S1PR1-5). S1PR1 was originally identified as an abundant transcript in endothelial cells and it has an important role in regulating endothelial cell cytoskeletal structure, migration, capillary-like network formation and vascular maturation. In addition, S1PR1 signaling is important in the regulation of lymphocyte maturation, migration and trafficking. Like the other members of the GPCR family, S1PR1 senses its ligand from outside the cell and activates intracellular signal pathways that at last lead to cellular responses. The signal is transduced through the association of the receptor with different G proteins, which recruits a series of systems for downstream amplification of the signal.

Specifications

Catalog number

ET1703-27

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

Yes

CAS Number

9000-83-3

Product Name Alternative

CD363 antibody CHEDG 1 antibody CHEDG1 antibody D1S3362 antibody ECGF 1 antibody ECGF1 antibody EDG 1 antibody EDG1 antibody endothelial differentiation G protein coupled receptor 1 antibody Endothelial differentiation G-protein coupled receptor 1 antibody Endothelial differentiation sphingolipid G protein coupled receptor 1 antibody FLJ58121 antibody G protein coupled sphingolipid receptor antibody g protein-coupled receptor edg-1 antibody S1P receptor 1 antibody S1P receptor Edg 1 antibody S1P receptor Edg-1 antibody S1P receptor Edg1 antibody S1P (1) receptor antibody S1P1 antibody s1pr1 antibody S1PR1_HUMAN antibody sphingolipid g-protein-coupled receptor 1 antibody Sphingosine 1 phosphate receptor Edg 1 antibody Sphingosine 1 phosphate receptor EDG1 antibody sphingosine 1- phosphate receptor 1 antibody Sphingosine 1-phosphate receptor 1 antibody Sphingosine 1-phosphate receptor Edg-1 antibody Sphingosine 1phosphate receptor type 1 S1P1 antibody

Abbreviation

S1P receptor 1, S1P1, S1P receptor Edg-1, S1PR1

Swiss Prot

P21453 Human, O08530 Mouse, P48303 Rat

Cellular Locus

Cell membrane.

Host

Rabbit

Species Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide within Human EDG1 aa 2-51 / 382.

Isotype

IgG

Conjugation

Non-conjugated

Type

Recombinant Rabbit monoclonal Antibody

Applications

WB, FC, IP

Positive Control

SH-SY5Y cell lysate, HepG2 cell lysate, bEnd.3 cell lysate, HepG2, HUVEC, SH-SY5Y, human breast carcinoma tissue, human liver tissue, mouse brain tissue, mouse heart tissue, Jurkat.

Concentration

1 mg/mL

Dilution

WB: 1:2,000-5,000 ;FC: 1:50-1:100 ;IP: Use at an assay dependent concentration.

Purity

Protein A affinity purified.

Form

Liquid

Buffer

1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

Predicted band size: 43 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Recombinant Antibody

Yes