TLR5 Recombinant Rabbit Monoclonal Antibody [JM10-88]

About this product

Toll-like receptor 5, also known as TLR5, is a protein which in humans is encoded by the TLR5 gene. It is a member of the toll-like receptor (TLR) family. The TLR family plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. TLR5 is expressed on both immune and non-immune cells. TLR5 recognizes bacterial flagellin, a principal component of bacterial flagella and a virulence factor. The activation of this receptor mobilizes the nuclear factor NF-κB and stimulates tumor necrosis factor-alpha production. TLR5 recognizes flagellin, which is the protein monomer that makes up the filament of bacterial flagella, found on nearly all motile bacteria. There are highly conserved regions in the flagellin protein among all bacteria, facilitating the recognition of flagellin by a germ-line encoded receptor such as TLR5. However, some Proteobacteria flagella have acquired mutations preventing their recognition by TLR5.

Specifications

Catalog number

ET1703-30

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9000-83-3

Product Name Alternative

FLJ10052 antibody MGC126430 antibody MGC126431 antibody SLEB1 antibody TIL 3 antibody TIL3 antibody TLR 5 antibody Tlr5 antibody TLR5_HUMAN antibody Toll like receptor 5 antibody Toll like receptor 5 precursor antibody Toll-like receptor 5 antibody Toll/interleukin 1 receptor like protein 3 antibody Toll/interleukin-1 receptor-like protein 3 antibody

Abbreviation

TLR5

Swiss Prot

O60602 Human, Q9JLF7 Mouse

Cellular Locus

Membrane.

Host

Rabbit

Species Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein within Human TLR5 aa 238-424 / 858.

Isotype

IgG

Conjugation

Non-conjugated

Type

Recombinant Rabbit monoclonal Antibody

Applications

WB, IHC-P

Positive Control

SK-Br-3 cells lysates, mouse testis tissue, mouse prostate tissue, mouse stomach tissue, human spleen tissue.

Concentration

1 mg/mL

Dilution

WB: 1:1,000-1:2,000 ;IHC-P: 1:50-1:200

Purity

Protein A affinity purified.

Form

Liquid

Buffer

1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

Predicted band size: 98 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Recombinant Antibody

Yes