FGFR3 Recombinant Rabbit Monoclonal Antibody [JM81-10]

About this product

Acidic and basic fibroblast growth factors (FGFs) are members of a family of multifunctional polypeptide growth factors that stimulate proliferation of cells of mesenchymal, epithelial and neuroectodermal origin. Like other growth factors, FGFs act by binding and activating specific cell surface receptors. These include the Flg receptor or FGFR-1, the Bek receptor or FGFR-2, FGFR-3, FGFR-4, FGFR-5 and FGFR-6. These receptors usually contain an extracellular ligand-binding region containing three immunoglobulin-like domains, a transmembrane domain and a cytoplasmic tyrosine kinase domain. The gene encoding human FGFR-3 maps to chromosome 4p16 and is alternatively spliced to produce three isoforms that are expressed in brain, kidney and testis. Defects in FGFR-3 are associated with several diseases, including Crouzon syndrome, achondroplasia, thanatophoric dysplasia, craniosynostosis adelaide type and hypochondroplasia. Mutations in FGFR-3 are also a cause of some bladder and cervical cancers.

Specifications

Catalog number

ET1703-36

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9000-83-3

Product Name Alternative

ACH antibody CD 333 antibody CD333 antibody CD333 antigen antibody CEK 2 antibody CEK2 antibody FGFR 3 antibody FGFR-3 antibody FGFR3 antibody FGFR3_HUMAN antibody Fibroblast growth factor receptor 3 (achondroplasia thanatophoric dwarfism) antibody Fibroblast growth factor receptor 3 antibody Heparin binding growth factor receptor antibody HSFGFR3EX antibody Hydroxyaryl protein kinase antibody JTK 4 antibody JTK4 antibody MFR 3 antibody SAM 3 antibody Tyrosine kinase JTK 4 antibody Tyrosine kinase JTK4 antibody Z FGFR 3 antibody

Abbreviation

FGFR-3, FGFR3

Swiss Prot

P22607 Human

Cellular Locus

Endoplasmic reticulum, Cell membrane, Cytoplasmic vesicle, Secreted.

Host

Rabbit

Species Reactivity

Human

Immunogen

Recombinant protein within Human FGFR3 aa 719-806 / 806.

Isotype

IgG

Conjugation

Non-conjugated

Type

Recombinant Rabbit monoclonal Antibody

Applications

WB, IF-Cell, IF-Tissue, IHC-P, FC, IP

Positive Control

HepG2 cell lysate, HEK-293 cell lysate, LNCaP cell lysate, A549 cell lysate, Hela, MCF-7, SH-SY5Y, human breast carcinoma tissue, human kidney tissue, HepG2.

Concentration

1 mg/mL

Dilution

WB: 1:5,000 ;IF-Cell: 1:50-1:200 ;IF-Tissue: 1:50-1:200 ;IHC-P: 1:50-1:200 ;FC: 1:50-1:100 ;IP: Use at an assay dependent concentration

Purity

Protein A affinity purified.

Form

Liquid

Buffer

1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

Predicted band size: 88 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Recombinant Antibody

Yes