SDHA Recombinant Rabbit Monoclonal Antibody [JM10-83]

About this product

In aerobic respiration reactions, succinate dehydrogenase (SDH) catalyzes the oxidation of succinate and ubiquinone to fumarate and ubiquinol. Four subunits comprise the SDH protein complex: a flavochrome subunit (SDHA), an iron-sulfur protein (SDHB), and two membrane-bound subunits (SDHC and SDHD) anchored to the inner mitochondrial membrane. Mutations to these subunits cause mitochondrial dysfunction, corresponding to several distinct disorders. Mutations in the membrane bound components may cause hereditary paraganglioma, while SDHA mutations are associated with juvenile encephalopathy as well as Leigh Syndrome, a severe neurological disorder. Inactivating mutations in SDHB correlate with inherited, but not necessarily sporadic, cases of pheochromocytoma.

Specifications

Catalog number

ET1703-40

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9000-83-3

Product Name Alternative

CMD1GG antibody DHSA_HUMAN antibody Flavoprotein subunit of complex II antibody Fp antibody PGL5 antibody SDH 2 antibody SDH1 antibody SDH2 antibody SDHA antibody SDHF antibody Succinate dehydrogenase [ubiquinone] flavoprotein subunit antibody Succinate dehydrogenase [ubiquinone] flavoprotein subunit mitochondrial antibody Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial antibody Succinate dehydrogenase complex flavoprotein subunit A antibody Succinate dehydrogenase complex flavoprotein subunit antibody Succinate dehydrogenase complex flavoprotein subunit precursor antibody Succinate dehydrogenase complex subunit A antibody Succinate dehydrogenase complex subunit A flavoprotein (Fp) antibody Succinate dehydrogenase complex subunit A flavoprotein antibody

Abbreviation

SDHA

Swiss Prot

P31040 Human, Q8K2B3 Mouse, Q920L2 Rat

Cellular Locus

Mitochondrion inner membrane.

Host

Rabbit

Species Reactivity

Human, Mouse, Rat, Zebrafish

Immunogen

Synthetic peptide within Human SDHA aa 581-624 / 664.

Isotype

IgG

Conjugation

Non-conjugated

Type

Recombinant Rabbit monoclonal Antibody

Applications

WB, IF-Cell, IF-Tissue, IHC-P, FC

Positive Control

Jurkat cell lysate, HL-60 cell lysate, HeLa cell lysate, MCF7 cell lysate, C2C12 cell lysate, L6 cell lysate, Mouse brain tissue lysate, Mouse heart tissue lysate, Rat brain tissue lysate, Rat heart tissue lysate, Zebrafish tissue lysate, HeLa, human kidney tissue, C2C12, human heart tissue, human liver tissue, mouse colon tissue, mouse skeletal muscle tissue, mouse testis tissue, mouse kidney tissue, rat kidney tissue, rat heart tissue, zebrafish tissue.

Concentration

1 mg/mL

Dilution

WB: 1:500-1:1,000 ;IF-Cell: 1:100-1:500 ;IF-Tissue: 1:200-1:1,000 ;IHC-P: 1:1,000-1:5,000 ;FC: 1:1,000

Purity

Protein A affinity purified.

Form

Liquid

Buffer

1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

Predicted band size: 73 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Recombinant Antibody

Yes