Growth Hormone Recombinant Rabbit Monoclonal Antibody [JM108-09]

About this product

Pituitary growth hormone (GH), also designated somatotropin, plays a crucial role in stimulating and controlling the growth, metabolism and differentiation of many mammalian cell types by modulating the synthesis of multiple mRNA species. These effects are mediated by the binding of GH to its membrane-bound receptor, GHR, and involve a phosphorylation cascade that results in the modulation of numerous signaling pathways. GH is secreted in a pulsatile pattern which is tightly controlled by the interplay of GH-releasing hormone (GHRH) and somatostatin (SRIF). GHRH and SRIF are the primary hypothalamic factors that determine GH secretion from the somatotroph and regulate GH synthesis and secretory reserve. GH output is also highly sensitive to feedback control by GH itself, as well as by insulin-like growth factor I. GH is synthesized by acidophilic or somatotropic cells of the anterior pituitary gland. Human growth hormone contains 191 amino acid residues with two disulfide bridges.

Specifications

Catalog number

ET1703-47

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9000-83-3

Product Name Alternative

gH antibody GH-N antibody GH1 antibody GHB5 antibody GHN antibody Growth hormone 1 antibody Growth hormone antibody Growth hormone B5 antibody Growth hormone, normal antibody Growth hormone, pituitary antibody HG1 antibody hGH-N antibody IGHD1B antibody Pituitary growth hormone antibody RNGHGP antibody SOMA_HUMAN antibody Somatotropin antibody

Abbreviation

GH, GH-N, GH1

Swiss Prot

P01241 Human

Cellular Locus

Secreted.

Host

Rabbit

Species Reactivity

Human

Immunogen

Synthetic peptide within Human Growth Hormone aa 72-106 / 217.

Isotype

IgG

Conjugation

Non-conjugated

Type

Recombinant Rabbit monoclonal Antibody

Applications

WB, IHC-P, IP

Positive Control

Human placenta tissue lysates, human tonsil tissue, human liver carcinoma tissue, human breast carcinoma tissue, human placenta tissue.

Concentration

1 mg/mL

Dilution

WB: 1:500 ;IHC-P: 1:50-1:1,000 ;IP: Use at an assay dependent concentration.

Purity

Protein A affinity purified.

Form

Liquid

Buffer

1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

Predicted band size: 25 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Recombinant Antibody

Yes