TNF Receptor II Recombinant Rabbit Monoclonal Antibody [JM113-01]

About this product

Tumor necrosis factor (TNF) is a pleiotropic cytokine whose function is mediated through two distinct cell surface receptors. These receptors, designated TNF-R1 and TNF-R2, are expressed on most cell types. The majority of TNF functions are primarily mediated through TNF-R1, while signaling through TNF-R2 occurs less extensively and is confined to cells of the immune system. Both of these proteins belong to the growing TNF and nerve growth factor (NGF) receptor superfamily, which includes FAS, CD30, CD27 and CD40. The members of this superfamily are type I membrane proteins that share sequence homology confined to the extracellular region. TNF-R1 shares a motif termed the "death domain" with FAS and three structurally unrelated signaling proteins, TRADD, FADD and RIP (1,3-8). This death domain is required for transduction of the apoptotic signal.

Specifications

Catalog number

ET1703-63

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

Yes

CAS Number

9000-83-3

Product Name Alternative

CD120b antibody p75 antibody p75 TNF receptor antibody p75TNFR antibody p80 TNF alpha receptor antibody p80 TNF-alpha receptor antibody Soluble TNFR1B variant 1 antibody TBP-2 antibody TBPII antibody TNF R II antibody TNF R2 antibody TNF R75 antibody TNF-R2 antibody TNF-RII antibody TNFBR antibody TNFR-II antibody TNFR1B antibody TNFR2 antibody TNFR80 antibody TNFRII antibody Tnfrsf1b antibody TNR1B_HUMAN antibody Tumor necrosis factor beta receptor antibody Tumor necrosis factor receptor 2 antibody Tumor necrosis factor receptor superfamily member 1B antibody Tumor necrosis factor receptor type II antibody Tumor necrosis factor-binding protein 2 antibody

Abbreviation

TNF-R2, TNF-RII, TNFR-II, TNFRSF1B

Swiss Prot

P20333 Human, P25119 Mouse, Q80WY6 Rat

Cellular Locus

Cell membrane, Membrane, Secreted.

Host

Rabbit

Species Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide within Human TNF Receptor II aa 426-461 / 461.

Isotype

IgG

Conjugation

Non-conjugated

Type

Recombinant Rabbit monoclonal Antibody

Applications

WB, IF-Cell, IF-Tissue, IHC-P, FC, IP, IHC-Fr

Positive Control

Jurkat cell lysate, RAW264.7 cell lysate, PC-12 cell lysate, C6 cell lysate, Mouse spleen tissue lysate, Rat spleen tissue lysate, human uterus tissue, HL-60, RAW264.7, PC-12.

Concentration

1 mg/mL

Dilution

WB: 1:500-1:2,000 ;IF-Cell: 1:50-1:200 ;IF-Tissue: 1:50-1:200 ;IHC-P: 1:50-1:200 ;FC: 1:50-1:100 ;IP: Use at an assay dependent concentration. ;IHC-Fr: 1:200

Purity

Protein A affinity purified.

Form

Liquid

Buffer

1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

Predicted band size: 48 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Recombinant Antibody

Yes