FGFR3 Recombinant Rabbit Monoclonal Antibody [JM110-33] — image 1 of 3

Product details

FGFR3 Recombinant Rabbit Monoclonal Antibody [JM110-33]

Catalog number ET1703-65

Discontinued

Price for ET1703-65

Size / count 100 µL

This variant is discontinued and cannot be added to your cart.

About this product

Acidic and basic fibroblast growth factors (FGFs) are members of a family of multifunctional polypeptide growth factors that stimulate proliferation of cells of mesenchymal, epithelial and neuroectodermal origin. Like other growth factors, FGFs act by binding and activating specific cell surface receptors. These include the Flg receptor or FGFR-1, the Bek receptor or FGFR-2, FGFR-3, FGFR-4, FGFR-5 and FGFR-6. These receptors usually contain an extracellular ligand-binding region containing three immunoglobulin-like domains, a transmembrane domain and a cytoplasmic tyrosine kinase domain. The gene encoding human FGFR-3 maps to chromosome 4p16 and is alternatively spliced to produce three isoforms that are expressed in brain, kidney and testis. Defects in FGFR-3 are associated with several diseases, including Crouzon syndrome, achondroplasia, thanatophoric dysplasia, craniosynostosis adelaide type and hypochondroplasia. Mutations in FGFR-3 are also a cause of some bladder and cervical cancers.

Specifications

Catalog number: ET1703-65
Size / count: 100 µL
Dry ice: No
Hazardous: No
Discontinued: Yes
CAS Number: 9000-83-3
Product Name Alternative: ACH antibody CD 333 antibody CD333 antibody CD333 antigen antibody CEK 2 antibody CEK2 antibody FGFR 3 antibody FGFR-3 antibody FGFR3 antibody FGFR3_HUMAN antibody Fibroblast growth factor receptor 3 (achondroplasia thanatophoric dwarfism) antibody Fibroblast growth factor receptor 3 antibody Heparin binding growth factor receptor antibody HSFGFR3EX antibody Hydroxyaryl protein kinase antibody JTK 4 antibody JTK4 antibody MFR 3 antibody SAM 3 antibody Tyrosine kinase JTK 4 antibody Tyrosine kinase JTK4 antibody Z FGFR 3 antibody
Abbreviation: FGFR-3, FGFR3
Swiss Prot: P22607 Human, Q61851 Mouse
Cellular Locus: Cell membrane, Endoplasmic reticulum, Cytoplasmic vesicle, Secreted.
Host: Rabbit
Species Reactivity: Human, Mouse, Rat
Immunogen: Synthetic peptide within Human FGFR3 aa 30-63 / 806.
Isotype: IgG
Conjugation: Non-conjugated
Type: Recombinant Rabbit monoclonal Antibody
Applications: WB, IF-Cell, IF-Tissue, IHC-P
Positive Control: Hela cell lysate, 293 cell lysate, MCF-7 cell lysate, HepG2 cell lysate, Rat skin tissue lysates, Mouse hippocampus lysates, MCF-7, HepG2, SH-SY5Y, human kidney tissue, mouse testis tissue, mouse kidney tissue, mouse brain tissue.
Concentration: 1 mg/mL
Dilution: WB: 1:1,000 ;IF-Cell: 1:50-1:200 ;IF-Tissue: 1:50-1:200 ;IHC-P: 1:50-1:200
Purity: Protein A affinity purified.
Form: Liquid
Buffer: 1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight: Predicted band size: 88 kDa
Storage Conditions: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Recombinant Antibody: Yes

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