PABPN1 Recombinant Rabbit Monoclonal Antibody [JM11-28]

About this product

Involved in the 3'-end formation of mRNA precursors (pre-mRNA) by the addition of a poly (A) tail of 200-250 nt to the upstream cleavage product. Stimulates poly (A) polymerase (PAPOLA) conferring processivity on the poly (A) tail elongation reaction and controls also the poly (A) tail length. Increases the affinity of poly (A) polymerase for RNA. Is also present at various stages of mRNA metabolism including nucleocytoplasmic trafficking and nonsense-mediated decay (NMD) of mRNA. Cooperates with SKIP to synergistically activate E-box-mediated transcription through MYOD1 and may regulate the expression of muscle-specific genes. Binds to poly (A) and to poly (G) with high affinity. May protect the poly (A) tail from degradation.

Specifications

Catalog number

ET1703-66

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9000-83-3

Product Name Alternative

Nuclear poly (A)-binding protein 1 antibody OPMD antibody PAB2 antibody PABII antibody PABP 2 antibody pABP-2 antibody PABP2 antibody PABP2_HUMAN antibody PABPII antibody Pabpn1 antibody poly (A) binding protein nuclear 1 antibody Poly (A)-binding protein 2 antibody Poly (A)-binding protein II antibody PolyA binding protein II antibody Polyadenylate-binding nuclear protein 1 antibody Polyadenylate-binding protein 2 antibody

Abbreviation

PABP-2, Poly (A)-binding protein 2, PABII, PABPN1

Swiss Prot

Q86U42 Human, Q8CCS6 Mouse

Cellular Locus

Cytoplasm, Nucleus.

Host

Rabbit

Species Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide within Human PABPN1 aa 4-51 / 306.

Isotype

IgG

Conjugation

Non-conjugated

Type

Recombinant Rabbit monoclonal Antibody

Applications

WB, IF-Cell, IF-Tissue, IHC-P, FC, IP

Positive Control

MCF-7 cell lysate, SH-SY5Y cell lysate, rat skin tissue lysate, AGS, SW480, mouse testis tissue, Hela.

Concentration

1 mg/mL

Dilution

WB: 1:500-1:2,000;IF-Cell: 1:50-1:200;IF-Tissue: 1:50-1:200;IHC-P: 1:50-1:200;FC: 1:50-1:100;IP: Use at an assay dependent concentration.

Purity

Protein A affinity purified.

Form

Liquid

Buffer

1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

Predicted band size: 33 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Recombinant Antibody

Yes