ERp57 Recombinant Rabbit Monoclonal Antibody [JM11-44]

About this product

Mammals defend themselves against intracellular pathogens through presentation of cytoplasmically-derived short pathogenic peptides to the cell surface of cytotoxic T lymphocytes, which subsequently leads to cytotoxic events with respect to the affected cell. Antigen presentation is mediated by major histocompatibility complex (MHC) class I molecules, which bind and coordinate short pathogenic peptides. MHC class I molecules assemble in the endoplasmic reticulum with chaperones before binding to the transporter associated with antigen processing (TAP). ERp57, also designated GRP57, GRP58, ERp60 and ERp61, is a component of the MHC class I pathway that appears to interact with MHC class I molecules before they associate with TAP. The human ERp57 gene maps to chromosome 15q15 and encodes a 505 amino acid protein. ERp57 has two Trp-Cys-Gly-His-Cys-Lys motifs completely conserved among the mammals. ERp57 may act as a protease, a protein disulfide isomerase, a phospholipase or a combination of these.

Specifications

Catalog number

ET1703-68

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9000-83-3

Product Name Alternative

58 kDa glucose regulated protein antibody 58 kDa glucose-regulated protein antibody 58 kDa microsomal protein antibody Disulfide isomerase ER 60 antibody Disulfide isomerase ER-60 antibody Endoplasmic reticulum resident protein 57 antibody Endoplasmic reticulum resident protein 60 antibody ER p57 antibody ER protein 57 antibody ER protein 60 antibody ERp 57 antibody ERp57 antibody ERp60 antibody ERp61 antibody Glucose Regulated Protein 58 Kd antibody GRP 57 antibody GRP 58 antibody GRP57 antibody HsT17083 antibody p58 antibody PDIA 3 antibody PDIA3 antibody PDIA3_HUMAN antibody Phospholipase C alpha antibody PI PLC antibody Protein disulfide isomerase A3 antibody Protein disulfide isomerase family A member 3 antibody Protein disulfide-isomerase A3 antibody

Abbreviation

p58, ER protein 57, ERp57, ER protein 60, ERp60, PDIA3

Swiss Prot

P30101 Human

Cellular Locus

Endoplasmic reticulum lumen. Melanosome.

Host

Rabbit

Species Reactivity

Human

Immunogen

Synthetic peptide within Human ERp57 aa 175-208 / 505.

Isotype

IgG

Conjugation

Non-conjugated

Type

Recombinant Rabbit monoclonal Antibody

Applications

WB, IP, IHC-P

Positive Control

HepG2 cell lysate, LNCaP cell lysate, human kidney tissue, human pancreas tissue, human uterus tissue.

Concentration

1 mg/mL

Dilution

WB: 1:1,000 ;IHC-P: 1:50-1:200 ;IP: 1:10-1:50

Purity

Protein A affinity purified.

Form

Liquid

Buffer

1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

Predicted band size: 57 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Recombinant Antibody

Yes