FMRP Recombinant Rabbit Monoclonal Antibody [JM91-41]

About this product

Fragile X syndrome is the most frequent form of inherited mental retardation and is the result of transcriptional silencing of the FMR1 gene on the X chromosome. The FMR1 gene contains a distinct CpG dinucleotide repeat located in the 5' untranslated region of the gene. In fragile X syndrome this tandem repeat is substantially amplified and subjected to extensive methylation and enhanced transcriptional silencing. The FMR1 protein (or FMRP) is an RNA-binding protein that associates with polyribosomes and is a likely component of a messenger ribonuclear protein (mRNP) particle. It contains several features that are characteristics of RNA-binding proteins, including two hnRNPK homology (KH) domains and an RGG amino acid motif (RGG box). FMR1 localizes to both the nucleus and the cytoplasm and can also interact with two fragile X syndrome related factors, FXR1 and FXR2, which form heterodimers through their N-terminal coiled-coil domains. Since FMR1 contains both a nuclear localization signal and a nuclear export signal it is also implicated in the nucleocytoplasmic transport of mRNAs.

Specifications

Catalog number

ET1703-70

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9000-83-3

Product Name Alternative

FMR 1 antibody Fmr1 antibody Fmr1 gene antibody FMR1_HUMAN antibody FMRP antibody Fragile X mental retardation 1 antibody Fragile X mental retardation 1 protein antibody Fragile X mental retardation protein 1 antibody Fragile X mental retardation protein antibody fragile X mental retardation syndrome-related protein 1 antibody fragile X mental retardation, autosomal homolog 1 antibody FRAXA antibody fxr1 antibody MGC87458 antibody POF antibody POF1 antibody Protein FMR-1 antibody Protein FMR1 antibody wu:fb16f11 antibody wu:fd18c10 antibody zgc:66226 antibody

Abbreviation

FMRP, Protein FMR-1, FMR1

Swiss Prot

Q06787 Human, P35922 Mouse, Q80WE1 Rat

Cellular Locus

Cell junction, Cell membrane, Cell projection, Centromere, Chromosome, Cytoplasm, Membrane, Nucleus, Postsynaptic cell membrane, Synapse, Synaptosome.

Host

Rabbit

Species Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide within human FMRP aa 20-60.

Isotype

IgG

Conjugation

Non-conjugated

Type

Recombinant Rabbit monoclonal Antibody

Applications

WB, IF-Cell, IF-Tissue, IHC-P

Positive Control

Hela cell lysate, K562 cell lysate, Daudi cell lysates, Hela, HepG2, SH-SY5Y, human tonsil tissue, rat brain tissue, mouse colon tissue, human brain tissue, mouse hippocampus tissue, mouse brain tissue.

Concentration

1 mg/mL

Dilution

WB: 1:1,000-1:5,000;IF-Cell: 1:100-1:500;IF-Tissue: 1:100-1:500;IHC-P: 1:50-1:1,000

Purity

Protein A affinity purified.

Form

Liquid

Buffer

1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

Predicted band size: 71 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Recombinant Antibody

Yes