FOXA2 Recombinant Rabbit Monoclonal Antibody [JM10-64]

Catalog number ET1703-76

Price for ET1703-76

Size / count 100 µL

About this product

Transcription factor that is involved in embryonic development, establishment of tissue-specific gene expression and regulation of gene expression in differentiated tissues. Is thought to act as a 'pioneer' factor opening the compacted chromatin for other proteins through interactions with nucleosomal core histones and thereby replacing linker histones at target enhancer and/or promoter sites. Binds DNA with the consensus sequence 5'-[AC]A[AT]T[AG]TT[GT][AG][CT]T[CT]-3' (By similarity). In embryonic development is required for notochord formation. Involved in the development of multiple endoderm-derived organ systems such as the liver, pancreas and lungs; FOXA1 and FOXA2 seem to have at least in part redundant roles. Originally discribed as a transcription activator for a number of liver genes such as AFP, albumin, tyrosine aminotransferase, PEPCK, etc. Interacts with the cis-acting regulatory regions of these genes. Involved in glucose homeostasis; regulates the expression of genes important for glucose sensing in pancreatic beta-cells and glucose homeostasis. Involved in regulation of fat metabolism. Binds to fibrinogen beta promoter and is involved in IL6-induced fibrinogen beta transcriptional activation.

Specifications

Catalog number: ET1703-76
Size / count: 100 µL
Dry ice: No
Hazardous: No
Discontinued: No
CAS Number: 9000-83-3
Product Name Alternative: Forkhead box A2 antibody Forkhead box protein A2 antibody FOX A2 antibody foxa2 antibody FOXA2_HUMAN antibody Hepatic nuclear factor 3 beta antibody Hepatocyte nuclear factor 3 antibody Hepatocyte nuclear factor 3 beta antibody Hepatocyte nuclear factor 3-beta antibody HNF 3B antibody HNF-3-beta antibody HNF-3B antibody HNF3B antibody MGC19807 antibody TCF 3B antibody TCF-3B antibody TCF3B antibody Transcription factor 3B antibody
Abbreviation: HNF-3-beta, HNF-3B, TCF-3B, FOXA2
Swiss Prot: Q9Y261 Human, P35583 Mouse, P32182 Rat
Cellular Locus: Nucleus. Cytoplasm.
Host: Rabbit
Species Reactivity: Human, Mouse, Rat
Immunogen: Synthetic peptide within human FOXA2 aa 1-50/457.
Isotype: IgG
Conjugation: Non-conjugated
Type: Recombinant Rabbit monoclonal Antibody
Applications: WB, IF-Cell, IHC-P, IHC-Fr
Positive Control: HT-29 cell lysate, A549 cell lysate, HepG2 cell lysate, HT-29, mouse liver tissue, rat liver tissue.
Concentration: 1 mg/mL
Dilution: WB: 1:1,000 ;IF-Cell: 1:100 ;IHC-P: 1:1,000 ;IHC-Fr: 1:200
Purity: Protein A affinity purified.
Form: Liquid
Buffer: 1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight: Predicted band size: 48 kDa
Storage Conditions: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Recombinant Antibody: Yes

Frequently Asked Questions

What is the catalog number for FOXA2 Recombinant Rabbit Monoclonal Antibody [JM10-64]?

The catalog number for FOXA2 Recombinant Rabbit Monoclonal Antibody [JM10-64] is ET1703-76.

What sizes are available for FOXA2 Recombinant Rabbit Monoclonal Antibody [JM10-64]?

FOXA2 Recombinant Rabbit Monoclonal Antibody [JM10-64] is available in the following size(s): 100 µL.

Is FOXA2 Recombinant Rabbit Monoclonal Antibody [JM10-64] in stock?

FOXA2 Recombinant Rabbit Monoclonal Antibody [JM10-64] is currently made to order / not held in immediate stock. Contact us for lead time.

What is FOXA2 Recombinant Rabbit Monoclonal Antibody [JM10-64] used for?

What should I do if I need to report a performance issue with a specific lot of this product?

Provide the catalogue number, product name, lot number, and your experimental results to our technical support team. They’ll investigate and, if needed, escalate to the manufacturer, provided the product was used before expiry and stored correctly.

What is the isotype of this antibody?

Isotype information such as IgG1 or IgG2a is listed in the product specifications on the datasheet, relevant for selecting compatible detection reagents.

Can I get a trial-size or discounted first order of this product?

We don’t generally offer free samples, but trial discounts in exchange for feedback and validation results are almost always possible. Contact us with your intended application to arrange one.