FGFR2 Recombinant Rabbit Monoclonal Antibody [JM10-60]

About this product

Acidic and basic fibroblast growth factors (FGFs) are members of a family of multifunctional polypeptide growth factors that stimulate proliferation of cells of mesenchymal, epithelial and neuroectodermal origin. Like other growth factors, FGFs act by binding and activating specific cell surface receptors. These include the Flg receptor or FGFR-1, the Bek receptor (or FGFR-2), FGFR-3, FGFR-4, FGFR-5 and FGFR-6. These receptors usually contain an extracellular ligand-binding region containing three immunoglobulin-like domains, a transmembrane domain and a cytoplasmic tyrosine kinase domain. The gene encoding human Bek (also designated K-sam) maps to chromosome 10q26.13 and is alternatively spliced to produce several isoforms. Heterogeneous mutations in Bek are associated with a range of craniosynostosis syndromes including Pfeiffer syndrome, Crouzon syndrome, Jackson-Weiss syndrome and Apert syndrome..

Specifications

Catalog number

ET1703-78

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9000-83-3

Product Name Alternative

bacteria-expressed kinase antibody BBDS antibody BEK antibody BEK fibroblast growth factor receptor antibody BFR1 antibody CD332 antibody CD332 antigen antibody CEK3 antibody CFD1 antibody Craniofacial dysostosis 1 antibody ECT1 antibody FGF receptor antibody FGFR 2 antibody FGFR-2 antibody Fgfr2 antibody FGFR2_HUMAN antibody Fibroblast growth factor receptor 2 antibody Hydroxyaryl protein kinase antibody Jackson Weiss syndrome antibody JWS antibody K SAM antibody K-sam antibody Keratinocyte growth factor receptor 2 antibody Keratinocyte growth factor receptor antibody KGFR antibody KSAM antibody protein tyrosine kinase, receptor like 14 antibody soluble FGFR4 variant 4 antibody TK14 antibody TK25 antibody

Abbreviation

FGFR-2, KGFR, FGFR2

Swiss Prot

P21802 Human, P21803 Mouse,

Cellular Locus

Cell membrane, Golgi apparatus, Cytoplasmic vesicle.

Host

Rabbit

Species Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide within Human FGFR2 aa 30-70 / 821.

Isotype

IgG

Conjugation

Non-conjugated

Type

Recombinant Rabbit monoclonal Antibody

Applications

WB, IP

Positive Control

HT-29 cell lysate, HaCaT cell lysate, PC-12 cell lysate, L6 cell lysate, Mouse brain tissue lysate, Rat brain tissue lysate, MCF7 cell lysate, NIH/3T3 cell lysate.

Concentration

1 mg/mL

Dilution

WB: 1:1,000-1:2,000 ;IP: 1:10-1:50

Purity

Protein A affinity purified.

Form

Liquid

Buffer

1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

Predicted band size: 92 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Recombinant Antibody

Yes