Endothelin B Receptor Recombinant Rabbit Monoclonal Antibody [JM74-10]

Catalog number ET1703-79

Price for ET1703-79

Size / count 100 µL

About this product

Endothelin receptor B (ETBR), also known as EDNRB, ETB, ETRB, HSCR and HSCR2, is a member of the guanine-binding, regulatory protein-coupled receptor family. Three isoforms of ETBR exist called isoform 1, isoform 2 and δ 3. ETBR is involved in the regulation of sodium excretion and glomular filtration rate (GFR). ETBR plays a role in the normal development of the neural crestderived cell lineages, epidermal melanocytes and enteric neurons. ETBR is expressed in lung, kidney, placenta, skeletal muscle and stem villi vessels. Both of the ET receptors, ETAR and ETBR, are activated by ET1, which results in inhibition of active lens sodium-potassium transport. Activation of the ET receptors also causes an increase in cytoplasmic calcium concentration in cultured lens epithelial cells. ETBR deficiency causes early onset dysfunction of the kidney, characterized by reduced sodium excretion, decreased GFR and slightly elevated blood pressure. Mutations in the gene encoding ETBR produce congenital aganglionic megacolon and pigment abnormalities. The multigenic disorder, Hirschsprung’s disease type 2, is also due to a mutation in the ETBR gene.

Specifications

Catalog number: ET1703-79
Size / count: 100 µL
Dry ice: No
Hazardous: No
Discontinued: No
CAS Number: 9000-83-3
Product Name Alternative: ABCDS antibody Ednra antibody EDNRB antibody EDNRB_HUMAN antibody Endothelin B receptor antibody Endothelin B receptor precursor antibody Endothelin receptor Non selective type antibody Endothelin receptor non-selective type antibody Endothelin receptor type B antibody ET B antibody ET-B antibody ET-BR antibody ETB antibody ETBR antibody ETRB antibody Hirschsprung disease 2 antibody HSCR antibody HSCR2 antibody OTTHUMP00000018534 antibody OTTHUMP00000178736 antibody WS4A antibody
Swiss Prot: P24530 Human
Cellular Locus: Cell membrane.
Host: Rabbit
Species Reactivity: Human, Zebrafish
Immunogen: Synthetic peptide within Human Endothelin B Receptor aa 58-91 / 442.
Isotype: IgG
Conjugation: Non-conjugated
Type: Recombinant Rabbit monoclonal Antibody
Applications: WB, IP
Positive Control: Zebrafish tissue lysate, Raji cell lysate, JAR cell lysate.
Concentration: 1 mg/mL
Dilution: WB: 1:500-1:2,000 ;IP: 1:10-1:50
Purity: Protein A affinity purified.
Form: Liquid
Buffer: 1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight: Predicted band size: 50 kDa
Storage Conditions: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Recombinant Antibody: Yes

Frequently Asked Questions

What is the catalog number for Endothelin B Receptor Recombinant Rabbit Monoclonal Antibody [JM74-10]?

The catalog number for Endothelin B Receptor Recombinant Rabbit Monoclonal Antibody [JM74-10] is ET1703-79.

What sizes are available for Endothelin B Receptor Recombinant Rabbit Monoclonal Antibody [JM74-10]?

Endothelin B Receptor Recombinant Rabbit Monoclonal Antibody [JM74-10] is available in the following size(s): 100 µL.

Is Endothelin B Receptor Recombinant Rabbit Monoclonal Antibody [JM74-10] in stock?

Endothelin B Receptor Recombinant Rabbit Monoclonal Antibody [JM74-10] is currently made to order / not held in immediate stock. Contact us for lead time.

What is Endothelin B Receptor Recombinant Rabbit Monoclonal Antibody [JM74-10] used for?

What documentation should I request if this product is used for a regulated or intellectual-property-sensitive application?

If the product is subject to intellectual property protections, we’ll advise on any MTA or usage restrictions before shipping. Let us know your intended end use so we can confirm what’s required upfront.

Is this antibody conjugated?

Conjugation status, such as unconjugated, HRP, FITC, or biotin, is specified in the product name and confirmed on the datasheet.

What is the sensitivity of this ELISA kit?

Assay sensitivity, including the minimum detectable dose, is listed on the datasheet. Kits that are assembled on order typically ship within 2-4 weeks.