CD26 Recombinant Rabbit Monoclonal Antibody [JM11-42]

About this product

CD26 (dipeptidylpeptidase 4, adenosine deaminase complexing protein 2, ADABP, ADCP2, DPPIV, TP103) is a membrane glycoprotein and a serine exopeptidase that cleaves X-proline dipeptides from the N-terminus of polypeptides. CD26 has an essential role in immune regulation as a T cell activation molecule and a regulator of chemokine function. CD26 associates with CXCR4 and gp120 and may influence the pathophysiology of HIV infection. Adenosine deaminase (ADA) colocalizing with adenosine receptors on dendritic cells are able to interact with CD26 expressed on lymphocytes. This costimulatory signal in the immunological synapse leads to an increase in the production of the T helper 1 and proinflammatory cytokines IFN-gamma, TNF-alpha, and IL-6. CD26 plays a role in the pathogenesis and behavior of human cancers, including solid tumors and hematological malignancies. CD26-caveolin-1 interaction plays a role in the up-regulation of CD86 on TT-loaded monocytes and subsequent engagement with CD28 on T cells, leading to antigen-specific T cell activation.

Specifications

Catalog number

ET1703-93

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

Yes

CAS Number

9000-83-3

Product Name Alternative

CD26 antigen antibody ADA-binding protein antibody ADABP antibody ADCP 2 antibody ADCP-2 antibody ADCP2 antibody Adenosine deaminase complexing protein 2 antibody CD 26 antibody CD26 antibody CD26 antigen 3 antibody Dipeptidyl peptidase 4 antibody Dipeptidyl peptidase 4 soluble form antibody Dipeptidyl peptidase IV antibody Dipeptidyl peptidase IV membrane form antibody Dipeptidyl peptidase IV soluble form antibody Dipeptidyl peptidase, intestinal antibody Dipeptidylpeptidase 4 antibody Dipeptidylpeptidase IV (CD26, adenosine deaminase complexing protein 2) antibody Dipeptidylpeptidase IV antibody DPP 4 antibody DPP IV antibody DPP IV estoenzyme antibody DPP4 antibody DPP4_HUMAN antibody DPPIV antibody Intestinal dipeptidyl peptidase antibody T cell activation antigen CD26 antibody T-cell activation antigen CD26 antibody TP 103 antibody TP103 antibody

Abbreviation

ADCP-2, DPP IV, DPP4

Swiss Prot

P27487 Human, P28843 Mouse, P14740 Rat

Cellular Locus

Secreted, Cell membrane, Apical cell membrane, invadopodium membrane, lamellipodium membrane, Cell junction, Membrane raft.

Host

Rabbit

Species Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide within Human CD26 aa 701-747 / 766 (Extracellular).

Isotype

IgG

Conjugation

Non-conjugated

Type

Recombinant Rabbit monoclonal Antibody

Applications

WB

Positive Control

LoVo cell lysate, Caco-2 cell lysate, mouse thymus tissue lysate, rat thymus tissue lysate, mouse liver tissue lysate, rat liver tissue lysate, human liver tissue, rat epididymis tissue.

Concentration

1 mg/mL

Dilution

WB: 1:2,000-1:5,000

Purity

Protein A affinity purified.

Form

Liquid

Buffer

1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

Predicted band size: 88 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Recombinant Antibody

Yes