NUR77 Recombinant Rabbit Monoclonal Antibody [JM59-11]

About this product

Nurr1 (Nur-related factor 1) and Nur77 (also designated NGFI-B) encode orphan nuclear receptors which may comprise an additional subfamily within the nuclear receptor superfamily. The rat and human homologs of mouse Nurr1 are designated RNR1 and NOT, respectively. Both Nurr1 and Nur77 are growth factor inducible immediate early response genes. Induction of both Nurr1 and Nur77 is seen after membrane depolarization while only Nur77 induction is seen with NGF stimulation. JunD acts as a mediator for Nur77. An increase in Nur77 expression is seen in activated T cells during G0 to G1 transition and throughout the G1 phase. In addition to its function as an immediate early gene, Nur77 may play a role in TCR-mediated apoptosis. Cyclosporin A, a potent immunosuppressant, has been shown to inhibit the ability of Nur77 to bind DNA. A dominant negative form of Nur77 can protect T cell hybridomas from activation-induced apoptosis. However, the absolute requirement of Nur77 for TCR-mediated apoptosis is still under debate.

Specifications

Catalog number

ET1703-97

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

Yes

CAS Number

9000-83-3

Product Name Alternative

Early response protein NAK1 antibody GFRP 1 antibody GFRP antibody GFRP1 antibody Growth factor inducible nuclear protein N10 antibody Growth Factor Inducible Nuclear Protein NP10 antibody Growth Factor Response Protein 1 antibody Hbr1 antibody HMR antibody Hormone Receptor antibody MGC9485 antibody N10 antibody N10 nuclear protein antibody NAK 1 antibody NAK1 antibody Nerve growth factor IB nuclear receptor variant 1 antibody NGFIB antibody NP 10 antibody NP10 antibody NR4A1 antibody NR4A1_HUMAN antibody Nuclear hormone receptor NUR/77 antibody Nuclear Hormone Receptor TR3 antibody Nuclear receptor subfamily 4 group A member 1 antibody NUR77 antibody NUR77, mouse, homolog of antibody Orphan nuclear receptor HMR antibody Orphan nuclear receptor NR4A1 antibody Orphan nuclear receptor TR3 antibody Orphan receptor tr3 antibody Receptor NGFIB antibody ST 59 antibody ST-59 antibody ST59 antibody Steroid receptor TR3 antibody Testicular receptor 3 antibody TR 3 antibody TR3 antibody TR3 orphan receptor antibody

Abbreviation

Nur77

Swiss Prot

P22736 Human, P12813 Mouse, P22829 Rat

Cellular Locus

Cytoplasm. Nucleus. Nucleus membrane.

Host

Rabbit

Species Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide within Human NUR77 aa 10-49 / 598.

Isotype

IgG

Conjugation

Non-conjugated

Type

Recombinant Rabbit monoclonal Antibody

Applications

WB, IF-Cell, IF-Tissue, IHC-P, FC

Positive Control

Rat brain tissue lysates, HepG2, Hela, NIH/3T3, human liver tissue, human colon carcinoma tissue, human breast tissue, mouse testis tissue, mouse ovarian tissue.

Concentration

1 mg/mL

Dilution

WB: 1:2,000-1:5,000 ;IF-Cell: 1:50-1:200 ;IF-Tissue: 1:50-1:200 ;IHC-P: 1:50-1:1,000 ;FC: 1;1,000

Purity

Protein A affinity purified.

Form

Liquid

Buffer

1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

Predicted band size: 64 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Recombinant Antibody

Yes