XRCC1 Recombinant Rabbit Monoclonal Antibody [JA11-47]

About this product

The x-ray repair cross-complementing (XRCC) proteins are responsible for efficiently repairing and maintaining genetic stability following DNA base damage. These genes share sequence similarity with the yeast DNA repair protein Rad5. XRCC1 is a protein that facilitates the DNA base excision repair pathway by interacting with DNA ligase III and DNA polymerase to repair DNA single-strand breaks. XRCC2 and XRCC3 are both involved in maintaining chromosome stability during cell division. XRCC2 is required for efficient repair of DNA double-strand breaks by homologous recombination between sister chromatids, and XRCC3 interacts directly with Rad51 to cooperate with Rad51 during recombinational repair. XRCC4 is an accessory factor of DNA ligase IV that preferentially binds DNA with nicks or broken ends. XRCC4 binds to DNA ligase IV and enhances its joining activity, and it is also involved in V (D)J recombination. Any defect in one of the known components of the DNA repair/V (D)J recombination machinery (Ku-70, Ku-80, DNA-PKCS, XRCC4 and DNA ligase IV) leads to abortion of the V (D)J rearrangement process and early block in both T and B cell maturation.

Specifications

Catalog number

ET1704-01

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9000-83-3

Product Name Alternative

DNA repair protein XRCC1 antibody RCC antibody X ray repair complementing defective repair in chinese hamster antibody X ray Repair Complementing Defective Repair in Chinese Hamster Cells antibody X ray repair complementing defective repair in chinese hamster cells 1 antibody X ray repair cross complementing 1 antibody X ray repair cross complementing protein 1 antibody X ray repair, complementing defective, repair in Chinese hamster antibody X ray repair cross-complementing protein 1 antibody XRCC 1 antibody Xrcc1 antibody XRCC1_HUMAN antibody

Abbreviation

XRCC1

Swiss Prot

P18887 Human, Q60596 Mouse, Q9ESZ0 Rat

Cellular Locus

Nucleus.

Host

Rabbit

Species Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide within Human XRCC1 aa 17-53 / 633.

Isotype

IgG

Conjugation

Non-conjugated

Type

Recombinant Rabbit monoclonal Antibody

Applications

WB, IHC-P

Positive Control

Hela cell lysate, mouse testis tissue, human breast infiltrating duct carcinoma tissue, human colon carcinoma tissue.

Concentration

1 mg/mL

Dilution

WB: 1:500-1:2,000 ;IHC-P: 1:50-1:200

Purity

Protein A affinity purified.

Form

Liquid

Buffer

1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

Predicted band size: 70 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Recombinant Antibody

Yes