DCAMKL1 Recombinant Rabbit Monoclonal Antibody [JA11-03]

About this product

Lissencephaly (smooth brain) is an abnormality of brain development characterized by incomplete neuronal migration and a smooth cerebral surface, manifesting as severe mental retardation. Genetic analysis has identified two proteins that are mutated in some cases of lissencephaly, designated lissencephaly-1 protein (LIS1) and doublecortin. LIS1 displays sequence homology to β-subunits of heterotrimeric G proteins, and doublecortin contains a consensus Abl phosphorylation site. In addition, the DCAMKL1 (doublecortinlike and CAM kinase-like 1) protein shows homology to doublecortin. All three proteins are highly expressed in developing brain and may function together to regulate microtubules involved in neuronal migration. The DCAMKL1 protein encodes a functional kinase that is capable of phosphorylating myelin basic protein and itself, but its kinase activity does not appear to affect its microtubule polymerization activity.

Specifications

Catalog number

ET1704-10

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9000-83-3

Product Name Alternative

Calcium/calmodulin-dependent protein kinase type I-like CPG16 antibody CL1 antibody CLICK1 antibody Cpg16 antibody DCDC3A antibody Dcl antibody Dclk antibody Dclk1 antibody DCLK1_HUMAN antibody Doublecortin domain-containing protein 3A antibody Doublecortin-like and CAM kinase-like 1 antibody Doublecortin-like kinase 1 antibody KIAA0369 antibody Serine/threonine-protein kinase DCAMKL1 antibody Serine/threonine-protein kinase DCLK1 antibody

Abbreviation

DCLK1

Swiss Prot

O15075 Human, Q9JLM8 Mouse, O08875 Rat

Cellular Locus

Plasma membrane.

Host

Rabbit

Species Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide within Human DCAMKL1 aa 649-698 / 740.

Isotype

IgG

Conjugation

Non-conjugated

Type

Recombinant Rabbit monoclonal Antibody

Applications

WB, IHC-P, IF-Cell, FC

Positive Control

SH-SY5Y cell lysate, NIH/3T3 cell lysate, C6 cell lysate, Mouse brain tissue lysate, Rat brain tissue lysate, SH-SY5Y, rat brain tissue.

Concentration

1 mg/mL

Dilution

WB: 1:1,000-1:2,000 ;IHC-P: 1:1,000 ;IF-Cell: 1:100 ;FC: 1:1,000

Purity

Protein A affinity purified.

Form

Liquid

Buffer

1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

Predicted band size: 82 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Recombinant Antibody

Yes