MHC Class II Recombinant Rabbit Monoclonal Antibody [JA10-94]

About this product

Major histocompatibility complex (MHC) molecules, also designated human leukocyte antigen (HLA) molecules, are cell-surface receptors that bind foreign peptides and present them to T lymphocytes. MHC class I molecules consist of two polypeptide chains, an α or heavy chain and β-2-Microglobulin, a non-covalently associated protein. Cytotoxic T lymphocytes bind antigenic peptides presented by MHC class I molecules. Antigens that bind to MHC class I molecules are typically eight to ten residues in length and are stabilized in a peptide binding groove. MHC class II molecules are encoded by polymorphic MHC genes and consist of a non-covalent complex of an α and β chain. Helper T lymphocytes bind antigenic peptides presented by MHC class II molecules. MHC class II molecules bind 13-18 amino acid antigenic peptides. Accumu-lating in endosomal/lysosomal compartments and on the surface of B cells, HLA-DM and -DO molecules regulate binding of exogenous peptides to class II molecules (HLA-DR) by sustaining a conformation that favors peptide exchange. The differential structural properties of MHC class I and class II molecules account for their respective roles in activating different populations of T lymphocytes.

Specifications

Catalog number

ET1704-13

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9000-83-3

Product Name Alternative

D6S221E antibody DMA antibody DMB antibody DP beta 1 antibody DP beta 1 chain antibody DP (W4) beta chain antibody DPB 1 antibody DPB1 antibody DPB1_HUMAN antibody DRB antibody H2Ea antibody HLA class II histocompatibility antigen antibody HLA class II histocompatibility antigen DM beta chain antibody HLA class II histocompatibility antigen, DP beta 1 chain antibody HLA class II histocompatibility antigen, DP (W4) beta chain antibody HLA DMB antibody HLA DP1A antibody HLA DPB1 antibody HLA SB alpha chain antibody HLA-A antibody HLA-A histocompatibility type antibody HLA-DP antibody HLA-DP histocompatibility type, beta-1 subunit antibody HLA-DP1B antibody HLA-DPB antibody HLA-DPB1 antibody HLADM antibody HLADP1B antibody HLASB antibody HLASB histocompatibility type antibody Human MHC class II HLA SB alpha antibody LA class II histocompatibility antigen DP alpha 1 chain antibody Major histocompatibility complex class II antibody Major histocompatibility complex class II DP alpha 1 antibody Major histocompatibility complex class II DP beta 1 antibody Major histocompatibility complex, class I, A antibody MHC class II antigen DMB antibody MHC class II antigen DPB1 antibody MHC class II DP3 alpha antibody MHC class II DPA1 antibody MHC class II HLA-DP-beta-1 antibody MHC DPB1 antibody MHC HLA DPB1 antibody PLT1 antibody Primed lymphocyte test 1 antibody RING6 antibody RING7 antibody

Abbreviation

HLA-DPB1

Swiss Prot

P04440 Human

Cellular Locus

Cell membrane. Endoplasmic reticulum membrane.

Host

Rabbit

Species Reactivity

Human

Immunogen

Synthetic peptide within Human HLA-DPB1 aa 11-60 / 258.

Isotype

IgG

Conjugation

Non-conjugated

Type

Recombinant Rabbit monoclonal Antibody

Applications

WB, IP, IF-Cell, IF-Tissue, IHC-P, mIHC

Positive Control

Daudi cell lysates, human tonsil tissue.

Concentration

1 mg/mL

Dilution

WB: 1:500-1:1,000 ;IF-Cell: 1:50-1:100 ;IF-Tissue: 1:50-1:100 ;IHC-P: 1:1,000 ;IP: Use at an assay dependent concentration. ;mIHC: 1:2,000

Purity

Protein A affinity purified.

Form

Liquid

Buffer

1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

Predicted band size: 29 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Recombinant Antibody

Yes