NFAT1 Recombinant Rabbit Monoclonal Antibody [JA11-08]

About this product

The NFAT (nuclear factor of activated T cells) family of transcription factors regulates cytokine expression in T cells. Members of the family include NFATc1 (NFATc), NFATc2 (NFATp), NFATn, NFATc3 (NFAT4, NFATx) and NFATc4 (NFAT3). Recognition of antigen by the T cell receptor (TCR) eventually activates the calcium-dependent protein phosphatase calcineurin. Once activated, calcineurin stimulates the translocation of NFATc1 (cytoplasmic) from the cytoplasm to the nucleus where it associates with NFATn (nuclear). Like NFATc1, NFATc2 resides in the cytoplasm and translocates to the nucleus subsequent to activation of calcineurin. Once in the nucleus, NFATc2 synergizes with AP-1 transcription factors to initiate transcription of cytokine genes. NFATc3 and NFATc4 share 65% sequence identity with other members of the NFAT family. They are similar to NFATc2 in that they also synergize with the AP-1 family of proteins.

Specifications

Catalog number

ET1704-14

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9000-83-3

Product Name Alternative

AI607462 antibody cytoplasmic 2 antibody KIAA0611 antibody NF ATc2 antibody NF ATp antibody NF-ATc2 antibody NF-ATp antibody NFAC2_HUMAN antibody NFAT 1 antibody NFAT pre existing subunit antibody NFAT pre-existing subunit antibody NFAT transcription complex, preexisting component antibody NFAT1 antibody NFAT1-D antibody NFATc2 antibody NFATp antibody Nuclear factor of activated T cells cytoplasmic 2 antibody Nuclear factor of activated T cells cytoplasmic calcineurin dependent 2 antibody Nuclear factor of activated T cells pre-existing component antibody Nuclear factor of activated T cells, preexisting component antibody Nuclear factor of activated T-cells antibody Preexisting nuclear factor of activated T cells 2 antibody T cell transcription factor NFAT 1 antibody T-cell transcription factor NFAT1 antibody

Abbreviation

NF-ATc2, NFATc2, NF-ATp, NFATC2

Swiss Prot

Q13469 Human

Cellular Locus

Cytoplasm. Nucleus.

Host

Rabbit

Species Reactivity

Human

Immunogen

Synthetic peptide within Human NFAT1 aa 21-70 / 925.

Isotype

IgG

Conjugation

Non-conjugated

Type

Recombinant Rabbit monoclonal Antibody

Applications

WB, IF-Tissue, IHC-P

Positive Control

Jurkat cell lysate, Ramos cell lysate, Raji cell lysate, Daudi cell lysate, human spleen tissue, human NK-T-cell lymphoma tissue, human colon cancer tissue.

Concentration

1 mg/mL

Dilution

WB: 1:1,000 ;IF-Tissue: 1:50-1:200 ;IHC-P: 1:1,000

Purity

Protein A affinity purified.

Form

Liquid

Buffer

1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

Predicted band size: 100 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Recombinant Antibody

Yes