PRMT1 Recombinant Rabbit Monoclonal Antibody [JA11-17]

About this product

A class of proteins termed type 1 protein arginine N-methyltransferase (PRMT) enzymes contribute to posttranslational modification of RNA-binding proteins, but differ in substrate specificities, oligomerization properties and subcellular localization. PRMT1, the predominant form in mammalian cells, is located in the nucleus, while PRMT3 is present in the cytoplasm. At the carboxy-terminus, interleukin enhancer-binding factor 3 (ILF3) binds PRMT1, thereby regulating PRMT1 activitiy. Alternative mRNA splicing of the PRMT gene results in three isoforms of PRMT1 that differ in their amino-terminus regions. All three splice variants of PRMT1 are enzymatically active. PRMT3 recognizes and binds to RNA-associated substrates with a zinc-finger domain in its amino-terminus. The zinc-liganded form of this domain is required for the enzyme to recognize RNA-associated substrates.

Specifications

Catalog number

ET1704-19

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9000-83-3

Product Name Alternative

ANM 1 antibody ANM1 antibody ANM1_HUMAN antibody HCP 1 antibody HCP1 antibody Heterogeneous nuclear ribonucleoprotein methyltransferase 1 like 2 antibody Heterogeneous nuclear ribonucleoproteins methyltransferase like 2 antibody Heterogeneous nuclear ribonucleoproteins methyltransferase like2 antibody Histone-arginine N-methyltransferase PRMT1 antibody HMT 2 antibody HMT1 (hnRNP methyltransferase S. cerevisiae) like 2 antibody HMT1 hnRNP methyltransferase antibody HMT1 hnRNP methyltransferase like 2 (S. cerevisiae) antibody HMT1 hnRNP methyltransferase like 2 antibody HMT2 antibody HRMT1 L2 antibody HRMT1L 2 antibody HRMT1L2 antibody Human mRNA for suppressor for yeast mutant antibody Human mRNA for suppressor for yeast mutant complete cds antibody Interferon receptor 1 bound protein 4 antibody Interferon receptor 1 bound protein4 antibody Interferon receptor 1-bound protein 4 antibody Interferon receptor 1bound protein 4 antibody IR1 B4 antibody IR1B 4 antibody IR1B4 antibody Mrmt 1 antibody Mrmt1 antibody PRMT 1 antibody PRMT1 antibody Protein arginine methyltransferase 1 antibody Protein arginine N methyltransferase 1 antibody Protein arginine N methyltransferase1 antibody Protein arginine N-methyltransferase 1 antibody R1B4 antibody S. cerevisiae like 2 antibody

Abbreviation

PRMT1

Swiss Prot

Q99873 Human, Q9JIF0 Mouse, Q63009 Rat

Cellular Locus

Nucleus. Cytoplasm.

Host

Rabbit

Species Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide within Human PRMT1 aa 12-61 / 371.

Isotype

IgG

Conjugation

Non-conjugated

Type

Recombinant Rabbit monoclonal Antibody

Applications

WB, IF-Cell, IF-Tissue, IHC-P

Positive Control

D3, NIH/3T3, Hela, HepG2, SW480, human breast carcinoma tissue, mouse liver tissue, mouse colon tissue.

Concentration

1 mg/mL

Dilution

WB: 1:500-1:1,000 ;IF-Cell: 1:100-1:500 ;IF-Tissue: 1:100-1:500 ;IHC-P: 1:50-1:200

Purity

Protein A affinity purified.

Form

Liquid

Buffer

1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

42 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Recombinant Antibody

Yes