IKK gamma Recombinant Rabbit Monoclonal Antibody [JA11-83]

About this product

Regulatory subunit of the IKK core complex which phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. Its binding to scaffolding polyubiquitin seems to play a role in IKK activation by multiple signaling receptor pathways. However, the specific type of polyubiquitin recognized upon cell stimulation (either 'Lys-63'-linked or linear polyubiquitin) and its functional importance is reported conflictingly. Also considered to be a mediator for TAX activation of NF-kappa-B. Could be implicated in NF-kappa-B-mediated protection from cytokine toxicity. Essential for viral activation of IRF3. Involved in TLR3- and IFIH1-mediated antiviral innate response; this function requires 'Lys-27'-linked polyubiquitination.

Specifications

Catalog number

ET1704-40

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9000-83-3

Product Name Alternative

IkB kinase associated protein 1 antibody IkB kinase subunit gamma antibody Inhibitor of nuclear factor kappa B kinase subunit gamma antibody AMCBX1 antibody FIP 3 antibody FIP-3 antibody FIP3 antibody Fip3p antibody I kappa B kinase gamma antibody I-kappa-B kinase subunit gamma antibody IkB kinase gamma subunit antibody IkB kinase subunit gamma antibody IkB kinase-associated protein 1 antibody Ikbkg antibody IKK-gamma antibody IKKAP1 antibody IKKG antibody IMD33 antibody Incontinentia pigmenti antibody Inhibitor of kappa light polypeptide gene enhancer in B cells, kinase gamma antibody Inhibitor of kappa light polypeptide gene enhancer in B cells, kinase of, gamma antibody Inhibitor of nuclear factor kappa-B kinase subunit gamma antibody IP antibody IP1 antibody IP2 antibody IPD2 antibody NEMO antibody NEMO_HUMAN antibody NF kappa B essential modifier antibody NF kappa B essential modulator antibody NF-kappa-B essential modifier antibody NF-kappa-B essential modulator antibody ZC2HC9 antibody

Abbreviation

NEMO, IKKAP1, I-kappa-B kinase subunit gamma, IKK-gamma, IKKG, IkB kinase subunit gamma, IKBKG, FIP3, NEMO

Swiss Prot

Q9Y6K9 Human, O88522 Mouse, Q6TMG5 Rat

Cellular Locus

Nucleus. Cytoplasm.

Host

Rabbit

Species Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein within Human IKK gamma aa 1-286 / 419.

Isotype

IgG

Conjugation

Non-conjugated

Type

Recombinant Rabbit monoclonal Antibody

Applications

WB, IHC-P, IF-Cell, IF-Tissue, IP, FC

Positive Control

Hela cell lysates, Hela, human spleen tissue, human colon carcinoma tissue, mouse colon tissue, mouse fallopian tissue, human colon tissue, human placenta tissue, mouse heart tissue,Hela, rat cerebellum tissue.

Concentration

1 mg/mL

Dilution

WB: 1:500-1:2,000;IF-Cell: 1:50-1:200;IF-Tissue: 1:50-1:200;IHC-P: 1:50-1:400;FC: 1:50-1:100;IP: Use at an assay dependent concentration.

Purity

Protein A affinity purified.

Form

Liquid

Buffer

1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

Predicted band size: 48 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Recombinant Antibody

Yes