GATA1 Recombinant Rabbit Monoclonal Antibody [JA10-32]

About this product

GATA-binding factor 1 or GATA-1 (also termed Erythroid transcription factor) is the founding member of the GATA family of transcription factors. This protein is widely expressed throughout vertebrate species. In humans and mice, it is encoded by the GATA1 and Gata1 genes, respectively. These genes are located on the X chromosome in both species. GATA1 regulates the expression (i.e. formation of the genes' products) of an ensemble of genes that mediate the development of red blood cells and platelets. Its critical roles in red blood cell formation include promoting the maturation of precursor cells, e.g. erythroblasts, to red blood cells and stimulating these cells to erect their cytoskeleton and biosynthesize their oxygen-carrying components viz., hemoglobin and heme. GATA1 plays a similarly critical role in the maturation of blood platelets from megakaryoblasts, promegakaryocytes, and megakaryocytes; the latter cells then shed membrane-enclosed fragments of their cytoplasm, i.e. platelets, into the blood. Reduced levels of GATA1 due to reductions in the translation of GATA1 mRNA into its transcription factor product are associated with promoting the progression of myelofibrosis, i.e. a malignant disease that involves the replacement of bone marrow cells by fibrous tissue and extramedullary hematopoiesis, i.e. the extension of blood cell-forming cells to sites outside of the bone marrow.

Specifications

Catalog number

ET1704-41

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9000-83-3

Product Name Alternative

Anemia, X-linked, without thrombocytopenia, included antibody ERYF 1 antibody Eryf1 antibody Erythroid transcription factor antibody Erythrold transcription factor 1 antibody GATA 1 antibody GATA binding factor 1 antibody GATA binding protein 1 (globin transcription factor 1) antibody GATA binding protein 1 antibody GATA-1 antibody GATA-binding factor 1 antibody GATA1 antibody GATA1_HUMAN antibody GF 1 antibody GF-1 antibody GF1 antibody Globin transcription factor 1 antibody NF E1 antibody NF E1 DNA binding protein antibody NF-E1 DNA-binding protein antibody NFE 1 antibody NFE1 antibody Nuclear factor erythroid 1 antibody Transcription factor GATA1 antibody XLANP antibody XLTDA antibody XLTT antibody

Abbreviation

GATA-1, GF-1, GATA1, ERYF1, GF1

Swiss Prot

P15976 Human

Cellular Locus

Nucleus.

Host

Rabbit

Species Reactivity

Human

Immunogen

Recombinant protein within human GATA1 aa 1-250.

Isotype

IgG

Conjugation

Non-conjugated

Type

Recombinant Rabbit monoclonal Antibody

Applications

WB, IHC-P, IP

Positive Control

K562 cell lysates, human breast carcinoma tissue, human liver tissue, human kidney tissue.

Concentration

1 mg/mL

Dilution

WB: 1:500-1:1,000 ;IHC-P: 1:50-1:200

Purity

Protein A affinity purified.

Form

Liquid

Buffer

1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

43 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Recombinant Antibody

Yes