CD163 Recombinant Rabbit Monoclonal Antibody [JA51-30]

About this product

CD163, also designated M130, is a macrophage-associated antigen that is a member of the scavenger receptor cysteine-rich (SRCR) superfamily. It is highly expressed on macrogphages and to a lesser extent on monocytes. The acute phase-regulated and signal-inducing macrophage protein, CD163, is a receptor that scavenges hemoglobin by mediating endocytosis of haptoglobin-hemoglobin complexes. CD163 binds only haptoglobin and hemoglobin in complex, which indicates the exposure of a receptor-binding neoepitope. The receptor-ligand interaction is calcium-dependent and of high affinity. The existence of several CD163 isoforms, which differ in the structure of their cytoplasmic domains and putative phosphorylation sites, suggests that these isoforms also differ in their signaling mechanism. The gene which encodes CD163 maps to human chromosome 12p13.31.

Specifications

Catalog number

ET1704-43

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9000-83-3

Product Name Alternative

C163A_HUMAN antibody CD 163 antibody CD163 antibody CD163 antigen antibody CD163 molecule antibody Hemoglobin scavenger receptor antibody M130 antibody M130 antigen precursor antibody Macrophage associated antigen antibody MM130 antibody OTTHUMP00000238617 antibody OTTHUMP00000238618 antibody OTTHUMP00000238619 antibody OTTHUMP00000238620 antibody SCARI1 antibody Scavenger receptor cysteine rich type 1 protein M130 antibody sCD163 antibody Soluble CD163 antibody

Abbreviation

sCD163, CD163, M130

Swiss Prot

Q86VB7 Human

Cellular Locus

Secreted, Cell membrane.

Host

Rabbit

Species Reactivity

Human

Immunogen

Recombinant protein within Human CD163 aa 1012-1149 / 1156.

Isotype

IgG

Conjugation

Non-conjugated

Type

Recombinant Rabbit monoclonal Antibody

Applications

WB, IHC-P, mIHC, IF-Tissue, IP

Positive Control

Human pancreatic carcinoma, human cervical cancer, human lung tissue lysates, human liver tissue lysates, human liver tissue, human spleen tissue, human placenta tissue, human tonsil tissue.

Concentration

1 mg/mL

Dilution

WB: 1:500-1:2,000 ;IHC-P: 1:1,000 ;mIHC: 1:2,000-1:3,000 ;IF-Tissue: 1:200 ;IP: Use at an assay dependent concentration.

Purity

Protein A affinity purified.

Form

Liquid

Buffer

1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

Predicted band size: 125 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Recombinant Antibody

Yes