hnRNP A1 Recombinant Rabbit Monoclonal Antibody [JA39-21]

About this product

Heterogeneous nuclear ribonucleoproteins (hnRNPs) constitute a set of poly-peptides that contribute to mRNA transcription and pre-mRNA processing as well as mature mRNA transport to the cytoplasm and translation. They also bind heterogeneous nuclear RNA (hnRNA), which are the transcripts produced by RNA polymerase II. There are approximately 20 known hnRNP proteins, and their complexes are the major constituents of the spliceosome. The majority of hnRNP protein components are localized to the nucleus; however some shuttle between the nucleus and the cytoplasm. The A/B subfamily of hnRNPs include A1, A2/B1, A3 and A0, and in Xenopus, hnRNP A1, A2 and A3 are ubiquitously expressed throughout development as well as in adult tissues. hnRNP A1 and A2/B1 regulate the processing of pre-mRNA by directly antagonizing the association of various splicing factors and by influencing the splice site selection on pre-mRNA. The hnRNP A0 gene is distinct from the other A/B family members, and it encodes a low-abundance protein, which is implicated in mRNA stability.

Specifications

Catalog number

ET1704-52

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9000-83-3

Product Name Alternative

HNRNPA 1 antibody Helix destabilizing protein antibody Helix-destabilizing protein antibody Heterogeneous nuclear ribonucleoprotein A1 antibody Heterogeneous nuclear ribonucleoprotein A1B protein antibody Heterogeneous nuclear ribonucleoprotein B2 protein antibody Heterogeneous nuclear ribonucleoprotein core protein A1 antibody hnRNP A1 antibody hnRNP core protein A1 antibody HNRNPA1 antibody HNRPA1 antibody MGC102835 antibody Nuclear ribonucleoprotein particle A1 protein antibody ROA1_HUMAN antibody Single strand DNA binding protein UP1 antibody Single strand RNA binding protein antibody Single-strand RNA-binding protein antibody

Abbreviation

HNRNPA1, HNRPA1

Swiss Prot

P09651 Human, P49312 Mouse, P04256 Rat

Cellular Locus

Nucleus. Cytoplasm.

Host

Rabbit

Species Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide within Human hnRNP A1 aa 301-350 / 372.

Isotype

IgG

Conjugation

Non-conjugated

Type

Recombinant Rabbit monoclonal Antibody

Applications

WB, IF-Cell, IHC-P, FC

Positive Control

HepG2 cell lysate, PC-12 cell lysate, MCF-7, Hela, HepG2, human tonsil tissue, human colon carcinoma tissue, human skin tissue, human breast carcinoma tissue, mouse colon tissue, Jurkat.

Concentration

1 mg/mL

Dilution

WB: 1:500-1:2,000;IF-Cell: 1:50-1:100;IHC-P: 1:100-1:500;FC: 1:50-1:100

Purity

Protein A affinity purified.

Form

Liquid

Buffer

1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

39 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Recombinant Antibody

Yes