DR5 Recombinant Rabbit Monoclonal Antibody [JA03-38]

About this product

Tumor necrosis factor (TNF) is a pleiotropic cytokine whose function is mediated by two distinct cell surface receptors, designated TNF-R1 and TNF-R2, which are expressed on most cell types. TNF function is primarily mediated through TNF-R1 signaling. Both receptors belong to the growing TNF receptor superfamily which includes FAS antigen and CD40. TNF-R1 contains a cytoplasmic motif, termed the "death domain," that has been found to be necessary for the transduction of the apoptotic signal. The death domain is also found in several other receptors, including FAS, DR2 (or TRUNDD), DR3 (Death Receptor 3), DR4 and DR5. TRUNDD, DR4 and DR5 are receptors for the apoptosis-inducing cytokine TRAIL. A non-death domain-containing receptor, designated decoy receptor (DcR1 or TRID), also specifically associates with TRAIL and may play a role in cellular resistance to apoptotic stimuli.

Specifications

Catalog number

ET1704-55

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9000-83-3

Product Name Alternative

Fas like protein antibody Apoptosis inducing protein TRICK2A/2B antibody Apoptosis inducing receptor TRAIL R2 antibody CD262 antibody CD262 antigen antibody Cytotoxic TRAIL receptor 2 antibody Death domain containing receptor for TRAIL/Apo 2L antibody Death receptor 5 antibody DR5 antibody KILLER antibody KILLER/DR5 antibody OTTHUMP00000123492 antibody OTTHUMP00000123493 antibody p53 regulated DNA damage inducible cell death receptor (killer) antibody TNF related apoptosis inducing ligand receptor 2 antibody TNF-related apoptosis-inducing ligand receptor 2 antibody TNFRSF10B antibody TR10B_HUMAN antibody TRAIL R2 antibody TRAIL receptor 2 antibody TRAIL-R2 antibody TRAILR2 antibody TRICK2 antibody TRICK2A antibody TRICK2B antibody TRICKB antibody Tumor necrosis factor receptor like protein ZTNFR9 antibody Tumor necrosis factor receptor superfamily member 10B antibody Tumor necrosis factor receptor superfamily, member 10b antibody ZTNFR9 antibody

Abbreviation

TRAIL receptor 2, TRAIL-R2, CD262, TNFRSF10B, DR5, KILLER, TRAILR2, TRICK2, ZTNFR9

Swiss Prot

O14763 Human

Cellular Locus

Membrane.

Host

Rabbit

Species Reactivity

Human

Immunogen

Synthetic peptide within Human DR5 aa 391-440 / 440.

Isotype

IgG

Conjugation

Non-conjugated

Type

Recombinant Rabbit monoclonal Antibody

Applications

WB, IP, IHC-P, FC

Positive Control

HL-60, human tonsil tissue, human liver tissue, human colon cancer tissue, human placenta tissue, SW480.

Concentration

1 mg/mL

Dilution

WB: 1:500-1:1,000 ;IHC-P: 1:50-1:200 ;FC: 1:50-1:100

Purity

Protein A affinity purified.

Form

Liquid

Buffer

1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

48 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Recombinant Antibody

Yes