MRP1 Recombinant Rabbit Monoclonal Antibody [JA93-03]

About this product

The two members of the large family of ABC transporters known to confer multidrug resistance in human cancer cells are the Mdr-1 P-glycoprotein and the multidrug-resistance protein MRP1. MRP1 is an integral membrane protein that contains an Mdr-like core, an N-terminal membrane-bound region and a cytoplasmic linker, and it is expressed in various cerebral cells, as well as in lung, testis and peripheral blood. The MRP gene family also includes MRP2, which is alternatively designated cMOAT (for canalicular multispecific organic anion transporter) and MRP3, which are both conjugate export pumps expressed predominantly in hepatocytes. MRP2 localizes exclusively to the apical membrane and is constitutively expressed at a high level in normal liver cells. Conversely, MRP3 localizes to the basolateral membrane where it also mediates the transport of the organic anion S- (2,4-dinitrophenyl-) glutathione toward the basolateral side of the membrane. MRP3 is normally expressed at comparatively lower levels than MRP2 and increases only when secretion across the apical membrane by MRP2 is impaired. MRP6 protein is highly expressed in liver and kidney, whereas MRP4 and MRP5 are detected in various tissues yet at much lower levels of expression.

Specifications

Catalog number

ET1704-56

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9000-83-3

Product Name Alternative

ABC 29 antibody ABC29 antibody ABCC 1 antibody ABCC antibody Abcc1 antibody ATP binding cassette sub family C (CFTR/MRP) member 1 antibody ATP binding cassette sub-family C member 1 antibody ATP binding cassette subfamily C member 1 antibody ATP binding cassette transporter variant ABCC1delta ex13 antibody ATP binding cassette transporter variant ABCC1delta ex13&14 antibody ATP binding cassette transporter variant ABCC1delta ex25 antibody ATP binding cassette transporter variant ABCC1delta ex25&26 antibody ATP binding cassette, sub-family C (CFTR/MRP), member 1 antibody ATP-binding cassette sub-family C member 1 antibody DKFZp686N04233 antibody DKFZp781G125 antibody GS X antibody GSX antibody Leukotriene C (4) transporter antibody LTC4 transporter antibody MRP 1 antibody MRP antibody MRP1 antibody MRP1_HUMAN antibody Multidrug resistance associated protein 1 antibody Multidrug resistance protein antibody Multidrug resistance-associated protein 1 antibody Multiple drug resistance associated protein antibody Multiple drug resistance protein 1 antibody

Abbreviation

LTC4 transporter, ABCC1, MRP, MRP1

Swiss Prot

P33527 Human

Cellular Locus

Cell membrane.

Host

Rabbit

Species Reactivity

Human

Immunogen

Synthetic peptide within Human MRP1 aa 1482-1531 / 1531.

Isotype

IgG

Conjugation

Non-conjugated

Type

Recombinant Rabbit monoclonal Antibody

Applications

WB, IHC-P, FC, IF-Cell

Positive Control

A549 cell lysate, HepG2 cell lysate, A549, human pancreas tissue, human tonsil tissue.

Concentration

1 mg/mL

Dilution

WB: 1:1,000 ;IHC-P: 1:50-1:200 ;FC: 1:1,000 ;IF-Cell: 1:100

Purity

Protein A affinity purified.

Form

Liquid

Buffer

1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

Predicted band size: 172 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Recombinant Antibody

Yes