PDCD4 Recombinant Rabbit Monoclonal Antibody [JA80-83]

About this product

The transformation suppressor gene Pdcd-4 (programmed cell death gene 4) inhibits the tumor-promoter mediated transformation of mouse keratinocytes and is a potential tumor suppressor gene in the development of human lung cancer. Biochemical analysis suggests that the Pdcd-4 protein is involved in protein translation as well as in nuclear events. Pdcd-4 directly interacts with the RNA helicase eIF4A and inhibits protein synthesis by interfering with the assembly of the cap-dependent translation initiation complex. Pdcd-4 also suppresses the transactivation of AP-1 responsive promoters by c-Jun, suggesting that the transformation-suppressor activity of Pdcd-4 might be due, at least in part, to the inhibition of c-Jun activity. In addition to affecting c-Jun phosphorylation, Pdcd-4 blocks the recruitment of the co-activator p300 by c-Jun.

Specifications

Catalog number

ET1704-70

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9000-83-3

Product Name Alternative

Death up-regulated gene protein antibody Dug antibody H731 antibody Ma3 antibody MGC33046 antibody MGC33047 antibody Neoplastic transformation inhibitor antibody Neoplastic transformation inhibitor protein antibody Nuclear antigen H731 antibody Nuclear antigen H731 like antibody Nuclear antigen H731 like protein antibody Nuclear antigen H731-like antibody PDCD 4 antibody Pdcd4 antibody PDCD4_HUMAN antibody Programmed cell death 4 antibody programmed cell death 4 (neoplastic transformation inhibitor) antibody Programmed cell death protein 4 antibody Protein 197/15a antibody Protein MA-3 antibody Tis antibody Topoisomerase-inhibitor suppressed protein antibody

Abbreviation

PDCD4, H731

Swiss Prot

Q53EL6 Human, Q61823 Mouse, Q9JID1 Rat

Cellular Locus

Nucleus. Cytoplasm.

Host

Rabbit

Species Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide within human PDCD4 aa 425-469/469.

Isotype

IgG

Conjugation

Non-conjugated

Type

Recombinant Rabbit monoclonal Antibody

Applications

WB, IF-Cell, IHC-P

Positive Control

Rat pancreas tissue lysate, Daudi cell lysate, A431, human tonsil tissue, mouse colon tissue, rat lung tissue.

Concentration

1 mg/mL

Dilution

WB: 1:500 ;IF-Cell: 1:100 ;IHC-P: 1:200-1:1,000

Purity

Protein A affinity purified.

Form

Liquid

Buffer

1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

Predicted band size: 52 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Recombinant Antibody

Yes