SPHK1 Recombinant Rabbit Monoclonal Antibody [JA31-14] — image 1 of 3

Product details

SPHK1 Recombinant Rabbit Monoclonal Antibody [JA31-14]

Catalog number ET1704-76

Price for ET1704-76

Size / count 100 µL

About this product

Sphingosine kinase (SphK or SphK1) is a key enzyme catalyzing the phosphorylation of sphingosine to form sphingosine 1-phosphate (SPP or S1P). Competitive inhibitors of SphK1 block formation of SPP and selectively inhibit cellular proliferation induced by a variety of factors. One potent inhibitor of SphK1 activity is DMS (N,N-dimethylsphingosine). SPP/SphK1 has been implicated as a signaling pathway that regulates diverse cellular functions, including cell growth, proliferation and survival. Specifically, SphK1 is involved in the signaling pathway (s) that protects human hepatocytes from the apoptotic action of TNFα. Furthermore, SPP/SphK1 may play an important role in neuronal survival by regulating activation of SAPKs and caspases. SphK1 is widely expressed with highest levels in adult liver, kidney, heart and skeletal muscle; however, activation of SphK1 disengages cells from their liver-specific phenotype.

Specifications

Catalog number: ET1704-76
Size / count: 100 µL
Dry ice: No
Hazardous: No
Discontinued: No
CAS Number: 9000-83-3
Product Name Alternative: SK 1 antibody SK1 antibody Sphingosine kinase 1 antibody SPHK 1 antibody SPHK antibody Sphk1 antibody SPHK1_HUMAN antibody SPK antibody SPK 1 antibody
Abbreviation: SK 1, SPK 1, SPHK1, SPHK, SPK
Swiss Prot: Q9NYA1 Human
Cellular Locus: Cytoplasm. Nucleus. Membrane.
Host: Rabbit
Species Reactivity: Human
Immunogen: Synthetic peptide within Human SPHK1 aa 25-74 / 384.
Isotype: IgG
Conjugation: Non-conjugated
Type: Recombinant Rabbit monoclonal Antibody
Applications: WB, IHC-P, FC
Positive Control: 293 cell lysate, MCF-7 cell lysate, human kidney tissue, Raji.
Concentration: 1 mg/mL
Dilution: WB: 1:500-1:1,000 ;IHC-P: 1:50-1:200 ;FC: 1:50
Purity: Protein A affinity purified.
Form: Liquid
Buffer: 1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight: 42 kDa
Storage Conditions: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Recombinant Antibody: Yes

Frequently Asked Questions

What is the catalog number for SPHK1 Recombinant Rabbit Monoclonal Antibody [JA31-14]?

The catalog number for SPHK1 Recombinant Rabbit Monoclonal Antibody [JA31-14] is ET1704-76.

What sizes are available for SPHK1 Recombinant Rabbit Monoclonal Antibody [JA31-14]?

SPHK1 Recombinant Rabbit Monoclonal Antibody [JA31-14] is available in the following size(s): 100 µL.

Is SPHK1 Recombinant Rabbit Monoclonal Antibody [JA31-14] in stock?

SPHK1 Recombinant Rabbit Monoclonal Antibody [JA31-14] is currently made to order / not held in immediate stock. Contact us for lead time.

What is SPHK1 Recombinant Rabbit Monoclonal Antibody [JA31-14] used for?

What is the sensitivity of this ELISA kit?

Assay sensitivity, including the minimum detectable dose, is listed on the datasheet. Kits that are assembled on order typically ship within 2-4 weeks.

Do you ship this product with dry ice?

Some products, including certain cell lines and biologics, require dry ice for transportation, which carries an additional fee shown clearly in your quotation. Dry ice delivery isn’t always possible to every destination due to transit time or local restrictions, so we check feasibility in advance and you must store the goods at the correct temperature the moment they arrive.

Is this product species cross-reactive?

Cross-reactivity data, based on available testing, is listed under the reactivity section of the datasheet. Contact us if you need reactivity confirmed for a species not listed.