TXNRD1 Recombinant Rabbit Monoclonal Antibody [JA11-32]

About this product

Thioredoxin (Trx) is a redox protein that is found in several species, such as bacteria, plants and mammals, and contains a conserved active site, consisting of Trp-Cys-Gly-Pro-Cys. Trx reductases (TrxR1 and TrxR2) are ubiquitous Ly noble flavoproteins that catalyze the NADPH-dependent reduction of Trx as well as several other oxidized cellular components. Mammalian Trx reductases are a part of a selenium-containing pyridine nucleotide-disulphide oxidoreductase family, which has a conserved catalytic site of Cys-Val- Asn-Val-Gly-Cys. TrxR1 and TrxR2 are also involved in the prevention of oxidative stress. Inhibition of TrxR activity may provide for potential treatments of cancer, AIDS and other autoimmune diseases as well as bacterial infections and parasitic diseases.

Specifications

Catalog number

ET1704-81

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9000-83-3

Product Name Alternative

cytoplasmic antibody Gene associated with retinoic and IFN-induced mortality 12 protein antibody Gene associated with retinoic and interferon-induced mortality 12 protein antibody Gene associated with retinoid IFN induced mortality 12 protein antibody GRIM 12 antibody GRIM-12 antibody GRIM12 antibody KDRF antibody KM 102 derived reductase like factor antibody KM-102-derived reductase-like factor antibody MGC9145 antibody Oxidoreductase antibody Thioredoxin reductase 1 antibody Thioredoxin reductase 1 cytoplasmic antibody Thioredoxin reductase GRIM 12 antibody Thioredoxin reductase TR1 antibody TR 1 antibody TR antibody TR1 antibody TRXR 1 antibody TRXR1 antibody TRXR1_HUMAN antibody TXNR antibody TXNRD 1 antibody Txnrd1 antibody

Abbreviation

TR, GRIM-12, TXNRD1, GRIM12, KDRF

Swiss Prot

Q16881 Human, Q9JMH6 Mouse, O89049 Rat

Cellular Locus

Cytoplasm. Nucleus.

Host

Rabbit

Species Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein with Human TXNRD1 aa 1-649 / 649.

Isotype

IgG

Conjugation

Non-conjugated

Type

Recombinant Rabbit monoclonal Antibody

Applications

WB, IF-Cell, IHC-P, IP, FC

Positive Control

Hela cell lysate, human liver tissue lysate, HUVEC, human kidney tissue, mouse testis tissue, SH-SY5Y.

Concentration

1 mg/mL

Dilution

WB: 1:500-1:2,000;IF-Cell: 1:50-1:200;IHC-P: 1:50-1:200;FC: 1:50-1:100

Purity

Protein A affinity purified.

Form

Liquid

Buffer

1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

55 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Recombinant Antibody

Yes