CLOCK Recombinant Rabbit Monoclonal Antibody [JA12-33]

About this product

Biological timepieces called circadian clocks are responsible for the regulation of hormonal rhythms, sleep cycles and other behaviors. The superchiasmatic nucleus (SCN), which is located in the brain, was the first mammalian circadian clock to be discovered. Clock, a member of the Basic-helix-loop-helix-psp (bHLH-PAS) family of transcription factors, has also been identified as having circadian function. Mutations within the clock gene have been shown to increase the length of the endogenous period and To contain a loss of rhythmicity of circadian oscillations. Clock contains a DNA-binding domain, a protein dimerization domain and a glutamine-rich C-terminal region, which indicates transactivation ability. It has been speculated that Clock may regulation circadian rhythmicity in combination with Other proteins such as Per. Per is also a PAS-domain containing protein that exhibits circadian function. Highest expression of Clock is seen in the hypothalamus and the eye.

Specifications

Catalog number

ET1704-82

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9000-83-3

Product Name Alternative

bHLHe8 antibody Circadian locomoter output cycles kaput protein antibody Circadian locomoter output cycles protein kaput antibody Circadian Locomotor Output Cycles Kaput antibody Circadium Locomotor Output Cycles Kaput antibody Class E basic helix-loop-helix protein 8 antibody CLOCK antibody Clock circadian regulator antibody Clock homolog antibody Clock protein antibody CLOCK_HUMAN antibody hCLOCK antibody KIAA0334 antibody

Abbreviation

hCLOCK, bHLHe8, CLOCK, BHLHE8, KIAA0334

Swiss Prot

O15516 Human, O08785 Mouse, Q9WVS9 Rat

Cellular Locus

Nucleus, Cytosol, Cytoplasm.

Host

Rabbit

Species Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide within Human CLOCK aa 140-189 / 846.

Isotype

IgG

Conjugation

Non-conjugated

Type

Recombinant Rabbit monoclonal Antibody

Applications

WB, IF-Cell, IF-Tissue, IHC-P, FC

Positive Control

HeLa cell lysate, HEK-293 cell lysate, NIH/3T3 cell lysate, PC-12 cell lysate, human brain tissue lysate, human fetal skeletal tissue, human colon tissue, human colon carcinoma tissue, human kidney tissue, PC-12.

Concentration

1 mg/mL

Dilution

WB: 1:500-1:5,000 ;IF-Cell: 1:50-1:200 ;IF-Tissue: 1:50-1:200 ;IHC-P: 1:50-1:200 ;FC: 1:50-1:100

Purity

Protein A affinity purified.

Form

Liquid

Buffer

1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

Predicted band size: 95 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Recombinant Antibody

Yes