Factor H Recombinant Rabbit Monoclonal Antibody [JA52-13]

About this product

The Factor H gene family is a multidomain, multifunctional protein family whose individual members are defined by conserved structural elements, which display diverse yet often overlapping functions. These proteins share a common structural motif, the short consensus repeat (SCR), which is structurally conserved among related genes and between phylogenetically divergent species. The human complement Factor H (FH, CFH, HUS, b-1H) gene encodes a 1213 amino acid serum glycoprotein which is arranged into 20 SCRs, each approximately 60 amino acids long, and an 18-residue leader sequence. Factor H controls the function of the alternative complement pathway and acts as a cofactor with Factor I (C3b inactivator). In addition, Factor H has functional activity outside of the complement system, where it can bind to the cellular integrin receptor (CD11b/CD18), interact with cell surface glycosaminoglycans and associate with the surface of certain pathogenic microorganisms. Deficiencies in Factor H is a common characteristic of acute renal disease.

Specifications

Catalog number

ET1704-83

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9000-83-3

Product Name Alternative

adrenomedullin binding protein antibody age related maculopathy susceptibility 1 antibody AHUS 1 antibody AHUS1 antibody AMBP 1 antibody AMBP1 antibody ARMD 4 antibody ARMD4 antibody ARMS 1 antibody ARMS1 antibody beta 1 H globulin antibody beta 1H antibody beta1H antibody CFAH_HUMAN antibody CFH antibody CFHL 3 antibody CFHL3 antibody Complement factor H antibody complement factor H, isoform b antibody Factor H antibody factor H like 1 antibody FH antibody FHL 1 antibody FHL1 antibody H factor 1 (complement) antibody H factor 1 antibody H factor 2 (complement) antibody HF 1 antibody HF 2 antibody HF antibody HF1 antibody HF2 antibody HUS antibody MGC88246 antibody

Abbreviation

CFH, HF, HF1, HF2

Swiss Prot

P08603 Human

Cellular Locus

Secreted.

Host

Rabbit

Species Reactivity

Human

Immunogen

Synthetic peptide within Human Factor H aa 131-180 / 1231.

Isotype

IgG

Conjugation

Non-conjugated

Type

Recombinant Rabbit monoclonal Antibody

Applications

WB, IF-Cell, IHC-P

Positive Control

Human kidney tissue lysates, Hela, HepG2, human liver tissue.

Concentration

1 mg/mL

Dilution

WB: 1:500-1:2,000 ;IF-Cell: 1:50-1:100 ;IHC-P: 1:50-1:100

Purity

Protein A affinity purified.

Form

Liquid

Buffer

1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

140 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Recombinant Antibody

Yes