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![Calpain 2 Recombinant Rabbit Monoclonal Antibody [JA43-41] — image 1 of 3](https://cdn.genprice.uk/products/992/68dd1c8b061270361ea815e7/imageurl/et1704-90.webp)
Product details
Catalog number ET1704-90
Price for ET1704-90
Size / count 100 µL
Calpain-2 is a heterodimer of a catalytic subunit encoded by CAPN2 gene and a regulatory subunit CAPNS1. The catalytic subunit consists of four domains: protease core 1 domain (PC1), protease core 2 domain (PC2), calpain-type beta-sandwich-like domain (CBSW), and penta EF-hand domain (PEF (L)). The catalytic cleft is formed by PC1 and PC2 upon calcium binding. The catalytic triad consists of residues C105, H262, and N286. Noteworthy, CAPN2 also contains an N-terminal anchor helix, which however is cleaved off upon protease activation. There is no known consensus sequence for calpain-2 proteolysis, but there is evidence for over 130 potential substrates. Proteolytic cleavage by calpain-2 is regulated by presence of Ca2+ ions. It requires supraphysiological (low millimolar) concentration of Ca2+ for activation. Intracellular concentration of Ca2+ (approx. 100 nM) is insufficient for activating calpain-2, so activation occurs upon influx of ions from extracellular space or from endoplasmic reticulum.
The catalog number for Calpain 2 Recombinant Rabbit Monoclonal Antibody [JA43-41] is ET1704-90.
Calpain 2 Recombinant Rabbit Monoclonal Antibody [JA43-41] is available in the following size(s): 100 µL.
Calpain 2 Recombinant Rabbit Monoclonal Antibody [JA43-41] is currently made to order / not held in immediate stock. Contact us for lead time.
Calpain-2 is a heterodimer of a catalytic subunit encoded by CAPN2 gene and a regulatory subunit CAPNS1. The catalytic subunit consists of four domains: protease core 1 domain (PC1), protease core 2 domain (PC2), calpain-type beta-sandwich-like domain (CBSW), and penta EF-hand domain (PEF (L)). The
Some products, including certain cell lines, plasmids, and tissue cultures, are subject to intellectual property terms and may require an MTA before we can ship. We’ll inform you in advance if this product requires one, and additional handling fees may apply.
Provide the catalogue number, product name, lot number, and your experimental results to our technical support team. They’ll investigate and, if needed, escalate to the manufacturer, provided the product was used before expiry and stored correctly.
Isotype information such as IgG1 or IgG2a is listed in the product specifications on the datasheet, relevant for selecting compatible detection reagents.
