CXCR3 Recombinant Rabbit Monoclonal Antibody [JA61-33]

About this product

Chemokine receptor CXCR3 is a Gαi protein-coupled receptor in the CXC chemokine receptor family. Other names for CXCR3 are G protein-coupled receptor 9 (GPR9) and CD183. CXCR3 is able to regulate leukocyte trafficking. Binding of chemokines to CXCR3 induces various cellular responses, most notably integrin activation, cytoskeletal changes and chemotactic migration. CXCR3-ligand interaction attracts Th1 cells and promotes Th1 cell maturation. As a consequence of chemokine-induced cellular desensitization (phosphorylation-dependent receptor internalization), cellular responses are typically rapid and short in duration. Cellular responsiveness is restored after dephosphorylation of intracellular receptors and subsequent recycling to the cell surface. A hallmark of CXCR3 is its prominent expression in in vitro cultured effector/memory T cells, and in T cells present in many types of inflamed tissues. In addition, CXCL9, CXCL10 and CXCL11 are commonly produced by local cells in inflammatory lesion, suggesting that CXCR3 and its chemokines participate in the recruitment of inflammatory cells. Additionally, CXCR3 has been implicated in wound healing.

Specifications

Catalog number

ET1704-97

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9000-83-3

Product Name Alternative

C-X-C chemokine receptor type 3 antibody CD 183 antibody CD182 antibody CD183 antibody Chemokine (C X C motif) receptor 3 antibody Chemokine (C X C) receptor 3 antibody Chemokine CXC Motif Receptor 3 antibody CKR L2 antibody CKR-L2 antibody CKRL2 antibody CMKAR3 antibody CXC-R3 antibody CXCR-3 antibody CXCR3 antibody CXCR3_HUMAN antibody G Protein Coupled Receptor 9 antibody G protein-coupled receptor 9 antibody GPR9 antibody Interferon-inducible protein 10 receptor antibody IP-10 receptor antibody IP10 antibody IP10 R antibody IP10 receptor antibody IP10-R antibody IP10R antibody Mig R antibody Mig receptor antibody Mig-R antibody MIGR antibody

Abbreviation

CXC-R3, CXCR-3, IP-10 receptor, IP-10 receptor, CD183, CXCR3, GPR9

Swiss Prot

P49682 Human

Cellular Locus

Cell membrane.

Host

Rabbit

Species Reactivity

Human

Immunogen

Recombinant protein within human CXCR3 aa 278-298 (Extracellular)/368.

Isotype

IgG

Conjugation

Non-conjugated

Type

Recombinant Rabbit monoclonal Antibody

Applications

WB

Positive Control

Human lung tissue lysate, K-562 cell lysate.

Concentration

1 mg/mL

Dilution

WB: 1:1,000

Purity

Protein A affinity purified.

Form

Liquid

Buffer

1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

Predicted band size: 41 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Recombinant Antibody

Yes