C4 Recombinant Rabbit Monoclonal Antibody [JM88-13]

About this product

Complement component 4 (C4), in humans, is a protein involved in the intricate complement system, originating from the human leukocyte antigen (HLA) system. It serves a number of critical functions in immunity, tolerance, and autoimmunity with the other numerous components. Furthermore, it is a crucial factor in connecting the recognition pathways of the overall system instigated by antibody-antigen (Ab-Ag) complexes to the other effector proteins of the innate immune response. For example, the severity of a dysfunctional complement system can lead to fatal diseases and infections. Complex variations of it can also lead to schizophrenia. Yet, the C4 protein derives from a simple two-locus allelic model, the C4A-C4B genes, that allows for an abundant variation in the levels of their respective proteins within a population. Originally defined in the context of the Chido/Rodgers blood group system, the C4A-C4B genetic model is under investigation for its possible role in schizophrenia risk and development.

Specifications

Catalog number

ET1705-10

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9000-83-3

Product Name Alternative

Acidic C4 antibody Acidic complement C4 antibody Basic C4 antibody Basic complement C4 antibody C3 and PZP-like alpha-2-macroglobulin domain-containing protein 2 antibody C3 and PZP-like alpha-2-macroglobulin domain-containing protein 3 antibody C4, Chido form antibody C4, Rodgers from antibody C4A anaphylatoxin antibody C4A antibody C4A2 antibody C4A3 antibody C4A4 antibody C4A6 antibody C4AD antibody C4B antibody C4B_2 antibody C4B1 antibody C4B12 antibody C4B2 antibody C4B3 antibody C4BD antibody C4F antibody C4S antibody CH antibody Chido form of C4 antibody CO4 antibody CO4A_HUMAN antibody Complement C4 gamma chain antibody complement C4-A antibody complement C4-B antibody complement C4-B-like antibody complement C4B1a antibody Complement component 4A (Rodgers blood group) antibody Complement component 4A antibody complement component 4B (Chido blood group), copy 2 antibody Complement component 4B (Childo blood group) antibody Complement component 4B antibody Complement component 4F antibody Complement component 4S antibody CPAMD2 antibody CPAMD3 antibody RG antibody Rodgers form of C4 antibody

Abbreviation

C4A, CO4, CPAMD2

Swiss Prot

P0C0L4 Human

Cellular Locus

Cell junction, Cell projection, Secreted, Synapse.

Host

Rabbit

Species Reactivity

Human

Immunogen

Synthetic peptide within Human C4 aa 1,231-1,280 / 1,744.

Isotype

IgG

Conjugation

Non-conjugated

Type

Recombinant Rabbit monoclonal Antibody

Applications

WB, IF-Cell, IF-Tissue, IHC-P

Positive Control

Human liver tissue lysates, HepG2, human liver tissue, human liver carcinoma tissue.

Concentration

1 mg/mL

Dilution

WB: 1:500-1:1,000 ;IF-Cell: 1:50-1:200 ;IF-Tissue: 1:50-1:200 ;IHC-P: 1:50-1:200

Purity

Protein A affinity purified.

Form

Liquid

Buffer

1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

Predicted band size: 193 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Recombinant Antibody

Yes